ID A0A2I2ZWB2_GORGO Unreviewed; 330 AA.
AC A0A2I2ZWB2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Death effector domain containing 2 {ECO:0000313|Ensembl:ENSGGOP00000051516.1};
GN Name=DEDD2 {ECO:0000313|Ensembl:ENSGGOP00000051516.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000051516.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000051516.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000051516.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000051516.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
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DR EMBL; CABD030113684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2ZWB2; -.
DR Ensembl; ENSGGOT00000065948.1; ENSGGOP00000051516.1; ENSGGOG00000009107.3.
DR GeneTree; ENSGT00390000008714; -.
DR InParanoid; A0A2I2ZWB2; -.
DR OMA; AFWSDYM; -.
DR Proteomes; UP000001519; Chromosome 19.
DR Bgee; ENSGGOG00000009107; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0030262; P:apoptotic nuclear changes; IEA:Ensembl.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IBA:GO_Central.
DR GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR038856; DEDD/DEDD2.
DR InterPro; IPR049341; TRADD-like_N.
DR PANTHER; PTHR15205; DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15205:SF1; DNA-BINDING DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01335; DED; 1.
DR Pfam; PF20694; TRADD-like_N; 1.
DR SMART; SM00031; DED; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50168; DED; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 25..104
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT REGION 103..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..174
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 330 AA; 36384 MW; 55D2E8CF7B446D27 CRC64;
MALSGSTSAP CWEEDECLDY YGMLSLHRMF EVVGGQLTEC ELELLAFLLD EAPGAAGGLA
RARSGLELLL ELERRGQCDE SNLRLLGQLL RVLARHDLLP HLARKRRRPG TGVTLPGRKG
YGTSSSSKRT EGSCRRRRQS SSSANSQQGQ WETGSPPTKR QRRSRGRPSG GARRRRRGAP
AAPQQQPEPA RPSSEGKVTC DIRLRVRAEY CEHGPALEQG VASRRPQALA RQLDVFGQAT
AVLRSRDLGS VVCDIKFSEL SYLDAFWGDY LSGALLQALR GVFLTEALRE AVGREAVRLL
VSVDEADYEA GRRRLLLMEE EGGRRPTEAS
//
