ID A0A2I2ZXX0_GORGO Unreviewed; 507 AA.
AC A0A2I2ZXX0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA polymerase delta subunit 2 {ECO:0000256|ARBA:ARBA00017588};
GN Name=POLD2 {ECO:0000313|Ensembl:ENSGGOP00000052071.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000052071.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000052071.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000052071.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000052071.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase delta/II small subunit
CC family. {ECO:0000256|ARBA:ARBA00006035}.
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DR EMBL; CABD030051050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2ZXX0; -.
DR STRING; 9593.ENSGGOP00000052071; -.
DR Ensembl; ENSGGOT00000052828.1; ENSGGOP00000052071.1; ENSGGOG00000004424.3.
DR GeneTree; ENSGT00390000006780; -.
DR InParanoid; A0A2I2ZXX0; -.
DR OMA; HCILIGT; -.
DR Proteomes; UP000001519; Chromosome 7.
DR Bgee; ENSGGOG00000004424; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0043625; C:delta DNA polymerase complex; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0016035; C:zeta DNA polymerase complex; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006271; P:DNA strand elongation involved in DNA replication; IBA:GO_Central.
DR GO; GO:0042276; P:error-prone translesion synthesis; IEA:Ensembl.
DR CDD; cd07387; MPP_PolD2_C; 1.
DR Gene3D; 2.40.50.430; -; 1.
DR Gene3D; 3.60.21.50; -; 1.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR040663; DNA_pol_D_N.
DR InterPro; IPR024826; DNA_pol_delta/II_ssu.
DR InterPro; IPR041863; PolD2_C.
DR PANTHER; PTHR10416; DNA POLYMERASE DELTA SUBUNIT 2; 1.
DR PANTHER; PTHR10416:SF0; DNA POLYMERASE DELTA SUBUNIT 2; 1.
DR Pfam; PF18018; DNA_pol_D_N; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 87..214
FT /note="DNA polymerase delta subunit OB-fold"
FT /evidence="ECO:0000259|Pfam:PF18018"
FT DOMAIN 234..449
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
SQ SEQUENCE 507 AA; 55605 MW; D573EB6FBA6B268C CRC64;
MEKKKKYSKS GRQHSERCGV NLLGLGEAVW TKQVRSVAMF SEQAAQRAHT LLSPPSANNA
TFARVPVATY TNSSQPFRLG ERSFSRQYAH IYATRLIQMR PFLENRAQQH WGSGVGVKKL
CELQPEEKCC VVGTLFKAMP LQPSILREIS EEHNLLPQPP RSKYIHPDDE LVLEDELQRI
KLKGTIDVSK LVTGTVLAVF GSVRDDGKFL VEDYCFADLA PQKPAPPLDT DRFVLLVSGL
GLGGGGGESL LGTQLLVDVV TGQLGDEGEQ CSAAHVSRVI LAGNLLSHST QSRDSINKAK
YLTKKTQAAS VEAVKMLDEI LLQLSASVPV DVMPGEFDPT NYTLPQQPLH PCMFPLATAY
STLQLVTNPY QATIDGVRFL GTSGQNVSDI FRYSSMEDHL EILEWTLRVR HISPTAPDTL
GCYPFYKTDP FIFPECPHVY FCGNTPSFGS KIIRGPEDQT VLLVTVPDFS ATQTACLVNL
RSLACQPISF SGFGAEDDDL GSLGLGP
//
