ID A0A2I2ZY38_GORGO Unreviewed; 488 AA.
AC A0A2I2ZY38;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Neurofascin {ECO:0000313|Ensembl:ENSGGOP00000051958.1};
GN Name=NFASC {ECO:0000313|Ensembl:ENSGGOP00000051958.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000051958.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000051958.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000051958.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000051958.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030008445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2ZY38; -.
DR Ensembl; ENSGGOT00000048712.1; ENSGGOP00000051958.1; ENSGGOG00000014728.3.
DR GeneTree; ENSGT00940000157024; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000014728; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05731; Ig3_L1-CAM_like; 1.
DR CDD; cd05845; IgI_2_L1-CAM_like; 1.
DR CDD; cd05875; IgI_hNeurofascin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026965; NFASC_Ig-like.
DR PANTHER; PTHR44170:SF12; NEUROFASCIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13927; Ig_3; 4.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..488
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014122793"
FT DOMAIN 43..139
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 145..232
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 263..351
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 356..443
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 488 AA; 54820 MW; 505EC4C750B97E15 CRC64;
MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNERKLT QPPTITKQSV KDHIVDPRDN
ILIECEAKGN PAPSFHWTRN SRFFNIAKDP RVSMRRRSGT LVIDFRSGGR PEEYEGEYQC
FARNKFGTAL SNRIRLQVSK SPLWPKENLD PVVVQEGAPL TLQCNPPPGL PSPVIFWMSS
SMEPITQDKR VSQGHNGDLY FSNVMLQDMQ TDYSCNARFH FTHTIQQKNP FTLKVLTNHP
YNDSSLRNHP DMYSARGVAE RTPSFMYPQG TTSSQMVLRG MDLLLECIAS GVPTPDIAWY
KKGGDLPSDK AKFENFNKAL RITNVSEEDS GEYFCLASNK MGSIRHTISV RVKAAPYWLD
EPKNLILAPG EDGRLVCRAN GNPKPTVQWM VNGEPLQSAP PNPNREVAGD TIIFRDTQIS
SRAVYQCNTS NEHGYLLANA FVSVLDVPPR MLSPRNQLIR VILYNRTRLD CPFFGSPIPT
LRCPHGLS
//
