ID A0A2I3BPX6_MOUSE Unreviewed; 820 AA.
AC A0A2I3BPX6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Scm-like with four mbt domains 1 {ECO:0000313|Ensembl:ENSMUSP00000153962.2};
GN Name=Sfmbt1 {ECO:0000313|Ensembl:ENSMUSP00000153962.2,
GN ECO:0000313|MGI:MGI:1859609};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000153962.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000153962.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000153962.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000153962.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000153962.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2I3BPX6; -.
DR SMR; A0A2I3BPX6; -.
DR ProteomicsDB; 320605; -.
DR Antibodypedia; 31362; 165 antibodies from 21 providers.
DR Ensembl; ENSMUST00000227303.2; ENSMUSP00000153962.2; ENSMUSG00000006527.17.
DR AGR; MGI:1859609; -.
DR MGI; MGI:1859609; Sfmbt1.
DR VEuPathDB; HostDB:ENSMUSG00000006527; -.
DR GeneTree; ENSGT00940000157363; -.
DR ChiTaRS; Sfmbt1; mouse.
DR Proteomes; UP000000589; Chromosome 14.
DR Bgee; ENSMUSG00000006527; Expressed in animal zygote and 230 other cell types or tissues.
DR ExpressionAtlas; A0A2I3BPX6; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20111; MBT_SFMBT1_rpt1; 1.
DR CDD; cd20113; MBT_SFMBT1_rpt2; 1.
DR CDD; cd20115; MBT_SFMBT1_rpt3; 1.
DR Gene3D; 2.30.30.140; -; 4.
DR Gene3D; 3.90.1150.190; SLED domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR047352; MBT_SFMBT1_rpt2.
DR InterPro; IPR047351; MBT_SFMBT1_rpt3.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR021987; SLED.
DR InterPro; IPR038348; SLED_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF77; SCM-LIKE WITH FOUR MBT DOMAINS PROTEIN 1; 1.
DR Pfam; PF02820; MBT; 4.
DR Pfam; PF12140; SLED; 1.
DR SMART; SM00561; MBT; 4.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 4.
DR PROSITE; PS51079; MBT; 4.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A0A2I3BPX6,
KW ECO:0007829|MaxQB:A0A2I3BPX6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 20..120
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 128..232
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 242..346
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 354..451
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 499..613
FT /note="SLED"
FT /evidence="ECO:0000259|Pfam:PF12140"
FT REGION 638..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..676
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..724
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 820 AA; 92318 MW; 4DEF70619CEE282F CRC64;
MSGEQQLDAD LGSGVEVEEF SWEDYLEETG STTVPYASFK HVDIRLQNGF APGMKLEVAL
KNDPETYWVA TIITACEQLL LLRYEGYGED RKADFWCDIR KAGLYPIGWC QQNKKTLEAP
EGIRDKVSDW NAFLQQTLIG ACGPPVSLLE GLRNGRNPLD LIAPGSKLEC QDFRDSLSTW
LVTVVENIGG RLKLRYEGLE SRDGFEHWLY YLDPFLHHIG WAAQQGCDLQ PPLAIKHLKS
EADWQEILAK VKEEEPLPSY LFKDKQVIGT HEFSINMKLE AVDPWSPFGI SPATIAKVFD
DKYFLVEMDD LRPEDHTRRS FVCHANSPGI FPVQWSLKNG LHINPPPGFR SQDFDWADYL
KQCGAEAAPQ KCFPQSISEH QFKENMKLEA VNPLFPEEVC IATVTAVRGS YLWLQLEGSK
KPVPEFIVSA ESMNIFPLGW CETNGHPLST PRRARGHKLR KIAVVQPEKQ ILSSRTVHEG
LKNQLNSTHS VMINGKYCCP KIYFNHRCFS GPYLNKGRIA ELPQCVGPGN CVLVLREVLT
LLINAAYKPS RVLRELQLDK DSVWHGCGEV LKAKYKGKSY RATVEIVRTA DRVTEFCRQT
CIKLECCPNL FGPRMVLDTC SENCSVLTKT KYTHYYGKKK NKRIGRPPGG HSNLSCALKK
SSKRRKRRKN IFVHKKKRSS ASVDNTPVGS PQGSGGEDEE DADDGDEDSL TEGSTSEQQE
ELQEESEVSE KKSSSSSPTQ SETPTPLPPD TQTNKRDAQT SSVSDDENKP PSPKEIDGQA
LLLLTLPTVQ ECMDLKLGPA IKLCHHIERI KFAFYEQFAN
//
