ID A0A2I3FRA7_NOMLE Unreviewed; 591 AA.
AC A0A2I3FRA7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Scm polycomb group protein homolog 1 {ECO:0000313|Ensembl:ENSNLEP00000024704.1};
GN Name=SCMH1 {ECO:0000313|Ensembl:ENSNLEP00000024704.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000024704.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000024704.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000024704.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SCM family. {ECO:0000256|ARBA:ARBA00008469}.
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DR EMBL; ADFV01076580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01076581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01076582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01076583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01076584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01076585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01076586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01076587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01076588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3FRA7; -.
DR Ensembl; ENSNLET00000051496.1; ENSNLEP00000024704.1; ENSNLEG00000012259.3.
DR GeneTree; ENSGT00940000157999; -.
DR Proteomes; UP000001073; Chromosome 12.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20108; MBT_SCMH1_rpt2; 1.
DR CDD; cd09578; SAM_Scm; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 3.90.1150.190; SLED domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR047280; MBT_SCMH1_rpt2.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR047531; SAM_Scm-like.
DR InterPro; IPR033763; SCML2_RBR.
DR InterPro; IPR021987; SLED.
DR InterPro; IPR038348; SLED_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF68; POLYCOMB PROTEIN SCMH1; 1.
DR Pfam; PF02820; MBT; 2.
DR Pfam; PF17208; RBR; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF12140; SLED; 1.
DR SMART; SM00561; MBT; 2.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51079; MBT; 2.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT REPEAT 1..79
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 87..188
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 524..589
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 186..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..286
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 591 AA; 65466 MW; E76672A32EF4D7FC CRC64;
MQSYTPPSNE FKISMKLEAQ DPRNTTSTCI ATVVGLTGAR LRLRLDGSDN KNDFWRLVDS
AEIQPIGNCE KNGGMLQPPL GFRLNASSWP MFLLKTLNGA EMAPIRIFHK EPPSPSHNFF
KMGMKLEAVD RKNPHFICPA TIGEVRGSEV LVTFDGWRGA FDYWCRFDSR DIFPVGWCSL
TGDNLQPPGT KVVIPKNPYP ASDVNTEKPS IHSSTKTVLE HQPGQRGRKP GKKRGRTPKT
LISHPISAPS KTAEPLKFPK KRGPKPGSKR KPRTLPNPPP ASPTTSTPEP DTSTVPQDAA
TIPSSAMQAP TVCIYLNKNG STGPHLDKKK VQQLPDHFGP ARASVVLQQA VQACIDCAYH
QKTVFSFLKQ GHGGEVISAV FDREQHTLNL PAVNSITYVL RFLEKLCHNL RSDNLFGNQP
FTQTHLSLTA TEYSHSHDRY LPGETFVLGN SLARSLEPHS DSMDSASNPT NLVSTSQRHR
PLLPSCGLPP STASAVRRLC SRGSDRYLES RDASRLSGRD PSSWTVEDVM QFVREADPQL
GPHADLFRKH QIDGKALLML RSDMMMKYMG VKLGPALKLS YHIDRLKQGK F
//
