ID A0A2I3FRM5_NOMLE Unreviewed; 371 AA.
AC A0A2I3FRM5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000024712.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000024712.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000024712.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR EMBL; ADFV01041795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3FRM5; -.
DR STRING; 61853.ENSNLEP00000024712; -.
DR Ensembl; ENSNLET00000047861.1; ENSNLEP00000024712.1; ENSNLEG00000035738.1.
DR GeneTree; ENSGT00940000161374; -.
DR InParanoid; A0A2I3FRM5; -.
DR Proteomes; UP000001073; Chromosome 12.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 7..290
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 371 AA; 42263 MW; 7B1FD2C711A50B55 CRC64;
MTGWSCLVTG AGGFLGQRII HLLVEEKELK EIRALDKAFR PKLREEFSYK NHSDNLSCVH
IELQNKTKLT VLEGDILDEP FLRRACQDMP VIIHITSIRD VIGVTHRLYF LTLTECFSLV
ASVPVFIYTS TLELARPNSY KEIIQNKPLE NTRSAPYPHS KKLAEKAVLA ANGWTLKNGG
TLYTCALRPM FIYGEGSPIL SASVNEALNN DGILSSFIKF SRVNLVYVGN VAWAHILAVR
ALRYRSKAPS VQGQFYYISD DTPHQSYDNL SYTLSKEFGL CLDSSWSLPL SLMCWIGFLL
EIVSFLLRPI YTCQPPFNRH RMTLSNSIFT FSYKKAQQDL AYNWEQAKQK TVEWVGSLVD
WHKDTLKSKT Q
//
