ID A0A2I3FRZ0_NOMLE Unreviewed; 1237 AA.
AC A0A2I3FRZ0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Pleckstrin homology and RhoGEF domain containing G2 {ECO:0000313|Ensembl:ENSNLEP00000024740.1};
GN Name=PLEKHG2 {ECO:0000313|Ensembl:ENSNLEP00000024740.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000024740.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000024740.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000024740.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01060131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01060132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012352242.1; XM_012496788.1.
DR AlphaFoldDB; A0A2I3FRZ0; -.
DR Ensembl; ENSNLET00000049038.1; ENSNLEP00000024740.1; ENSNLEG00000014390.3.
DR GeneTree; ENSGT00940000162093; -.
DR Proteomes; UP000001073; Chromosome 17.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13243; PH_PLEKHG1_G2_G3; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR043324; PH_PLEKHG1_G2_G3.
DR PANTHER; PTHR45924; FI17866P1; 1.
DR PANTHER; PTHR45924:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 43..224
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 254..352
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 375..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 978..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1103..1162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1204..1237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..1000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1017..1031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1126..1140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1237 AA; 133383 MW; 277219D5D87F9389 CRC64;
MPEGAQGLSL SKPSLSLGCG RRGEVCDCGT VCETRTGSAK PSRLERVARE IVETERAYVR
DLRSIVEDYL GPLLDGGVLG LSVEQVGTLF ANIEDIYEFS SELLEDLENS SSAGGIAECF
VQRSEDFDIY TLYCMNYPSS LALLRELSLS PPAALWLQER QAQLRHSLPL QSFLLKPVQR
ILKYHLLLQE LGKHWAEGPG TGGREMVEEA IVSMTAVAWY INDMKRKQEH AARLQEVQRR
LGGWTGPELS AFGELVLEGA FRGGGGGGPR LRGGERLLFL FSRMLLVAKR RGLEYTYKGH
IFCCNLSVSE SPRDPLGFKV SDLTIPKHRH LLQAKNQEEK RLWIHCLQRL FFENHPASIP
AKAKQVLLEN SLHCAPKSKP VPEPLTPPLG SPRPRDARSF TPGRRNTAPS PGPSVIRRGR
RQSEPVKDPY VMFPQNAKPG FKHAGSEGEL YPPESQPPVS GSGPPEDLED AGPPTLDPSG
PSITEEILEL LNQRGLRDPG PSTHDIPKFP GDSQVPRDSE TLTFQALPSR DSSEEEEEEE
EGLEMDERGP SPLHVLEGLE SSIAAEMPSI PCLTKIADVP NLPEIPSHCE IPEGSRIPSL
PDISDVFEMP CLPAIPSVPD APSLSSTPTL SCDSWLQGPL QEPAEAPATR RELFSGSNPG
KLGEPPSGGK AGPEEDEEGV SFTDFQLQDV TQHQGFPDEL AFRSCSEIRS AWQALEQGQL
ARPGFPEPLL ILEDSDLGGD SGSRKAGAPS SERTASRVRE LARLYSERIQ QMQRAETRAS
ANAPRRRPRV LAQPQPSPCL PQEQAEPGLL PAFGHVLVCE LAFPLTCAQE SVPLGPAAWV
QAAIPLSKQG GSPDGQGLHV SNLPKQDHPG IHVSAATLLP EQGGSRHVQA PAATPLPKQE
GPLHLQVPAL TTLPDQGHPE IQVPATTPLP EYRSHVAKPA PSTAFCPEQG HCGDIHVPTT
PTLPKEICSD FTVSVTTPVP KQEGHLDSES PTNIPLTKQG GSRDVQGPDP VCSQPIQPLS
LHGSSLDPQS PGDTLPPLPC HLPDLQIPGS SPLPAHGSHL DHRIPANAPL SLSQGLPDTQ
IPATTPLPLP QVLTDIWVQA LPTSPRQGSL PDIQGPAAAP PLPEPSLTDT QVQKLTPLLE
QKSLTDAHVP AATPLPERGG SLDIQGLLPT PVQTTMVLSK PGGSLASHIA RNLWAFPGPK
GLLMPPSTCE PGHEASPKQG LQPHAIDPQN LTRKSRH
//
