ID A0A2I3FTZ6_NOMLE Unreviewed; 636 AA.
AC A0A2I3FTZ6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Basic helix-loop-helix ARNT like 2 {ECO:0000313|Ensembl:ENSNLEP00000024996.1};
GN Name=BMAL2 {ECO:0000313|Ensembl:ENSNLEP00000024996.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000024996.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000024996.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000024996.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01029485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01029486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01029487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01029488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01029489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01029490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003265682.1; XM_003265634.3.
DR AlphaFoldDB; A0A2I3FTZ6; -.
DR STRING; 61853.ENSNLEP00000024996; -.
DR Ensembl; ENSNLET00000054177.1; ENSNLEP00000024996.1; ENSNLEG00000005463.3.
DR GeneID; 100601744; -.
DR KEGG; nle:100601744; -.
DR CTD; 56938; -.
DR GeneTree; ENSGT00940000160423; -.
DR InParanoid; A0A2I3FTZ6; -.
DR OMA; RIKCSRI; -.
DR OrthoDB; 2872674at2759; -.
DR Proteomes; UP000001073; Chromosome 23.
DR GO; GO:1990513; C:CLOCK-BMAL transcription complex; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0070888; F:E-box binding; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:Ensembl.
DR GO; GO:0042753; P:positive regulation of circadian rhythm; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd11469; bHLH-PAS_ARNTL2_PASD9; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR23042:SF48; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR23042; CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 107..160
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 178..243
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 378..427
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 26..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 636 AA; 71055 MW; 87A4935B76E1AD4F CRC64;
MAAEEEAAAG GKVLREENQC IAPVVSSRVS PGTRPTAVGS FSSHVTEFPQ KRKGSDSDPS
QSGIMTEKVV EKLSQNPLTY LLSTRIEISA SSGSRVEDGE HQVRMKAFRE AHSQTEKRRR
DKMNNLIEEL SAMIPQCNPM ARKLDKLTVL RMAVQHLRSL KGLTNSYVGN NYRPSFLQDN
ELRHLILKTA EGFLFVVGCE RGKILFVSKS VSKILNYDQA SLTGQSLFDF LHPKDVAKVK
EQLSSFDISP REKLIDAKTG LQVHSNFHTG RTRVYSGSRR SFFCRIKSCK ISVKEEHGRL
PNSKKKEHRK FYTIHCTGYL RSWPPSIVGM EEERNSKKDN SNFTCLVAIG RLQPYIVPQN
SGEINVKPTE FITRFAVNGK FVYVDQRATA ILGYLPQELL GTSCYEYFHQ DDHNNLTDKH
KAVLQSKEKI LTDSYKFRAK DGSFVTLKSQ WFSFTNPWTK ELEYIVSVNT LVLGHSEPGE
ASFFPCSSQS SEESSRQSCV SVPGMSTGTV LGAGSIGTDI ANEILDLQRL QSSSYLDDSN
PTDLMKDTHT VNCRSMSNKE LFPPSPSEMG ELEATRQNRS TVAVHSHEPL LSDGAQLDFD
ALCDNDDTAM AAFMNYLEAE GGLGDPGDFS DIQWTL
//
