ID A0A2I3FV37_NOMLE Unreviewed; 1122 AA.
AC A0A2I3FV37;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A10 {ECO:0000313|Ensembl:ENSNLEP00000025147.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000025147.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000025147.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000025147.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362035}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01031835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3FV37; -.
DR Ensembl; ENSNLET00000041071.1; ENSNLEP00000025147.1; ENSNLEG00000002041.3.
DR GeneTree; ENSGT00940000156972; -.
DR Proteomes; UP000001073; Chromosome 17.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022853; F:active monoatomic ion transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR GO; GO:0098660; P:inorganic ion transmembrane transport; IEA:UniProt.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF32; SODIUM-DRIVEN CHLORIDE BICARBONATE EXCHANGER; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 517..539
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 604..627
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 634..652
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 732..750
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 770..788
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 815..834
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 855..879
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 915..937
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1010..1027
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 154..441
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 488..993
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 66..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..83
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1122 AA; 126286 MW; C9B88D969C37FF0A CRC64;
SEKLSGNRLL MSKNGGTCYT LLLQGNDEEA VVDRGGTRSI LKTHFEKEDL EGHRTLFIGV
HVPLGGRKSH RRHRHRGHKH RKRDRERDSG LEDGRESPSF DTPSQRVQFI LGTEDDDEEH
IPHDLFTELD EICWREGEDA EWRETARWLK FEEDVEDGGE RWSKPYVATL SLHSLFELRS
CILNGTVLLD MHANTLEEIA DMVLDQQVSS GQLNEDVRHR VHEALMKQHH HQNQKKLTNR
IPIVRSFADI GKKQSEPNSM DKNGQVVSPQ SAPACVENKN DVSRENSTVD FSKGLGGQQK
GHTSPCGMKQ RHEKGPPHQQ EREVDLHFMK KIPPGAEASN ILVGELEFLD RTVVAFVRLS
PAVLLQGLAE VPIPTRFLFI LLGPLGKGQQ YHEIGRSIAT LMTDEVFHDV AYKAKDRNDL
VSGIDEFLDQ VTVLPPGEWD PSIRIEPPKN VPSQEKRKIP AVPNGTAAHG EAEPHGGHSG
PELQRTGRIF GGLILDIKRK APYFWSDFRD AFSLQCLASF LFLYCACMSP VITFGGLLGE
ATEGRISAIE SLFGASMTGI AYSLFGGQPL TILGSTGPVL VFEKILFKFC KEYGLSYLSL
RASIGLWTAT LCIILVATDA SSLVCYITRF TEEAFASLIC IIFIYEALEK LFELSEAYPI
NMHNDLELLT QYSCNCVEPH NPSNDTLKEW RESNISASDI IWENLTVSEC KSLHGEYVGR
ACGHDHPYVP DVLFWSVILF FSTVTLSATL KQFKTSRYFP TKVRSIVSDF AVFLTILCMV
LIDYAIGIPS PKLQVPSPTR DDRGWFVTPL GPNPWWTVIA AIIPALLCTI LIFMDQQITA
VIINRKEHKL KKGCGYHLDL LMVAVMLGVC SIMGLPWFVA ATVLSITHVN SLKLESECSA
PGEQPKFLGI REQRVTGLMI FILMGSSVFM TSILKFIPMP VLYGVFLYMG ASSLKGIQFF
DRIKLFWMPA KHQPDFIYLR HVPLRKVHLF TIIQMSCLGL LWIIKVSRAA IVFPMMVLAL
VFVRKLMDLL FTKRELSWLD DLMPESKKKK LEDAEKEEEQ SMLAMEDEGT VQLPLEGHYR
DDPSVINISD EMSKTALWRN LLITADNSKD KESSFPSKSS PS
//
