ID A0A2I3FWG4_NOMLE Unreviewed; 317 AA.
AC A0A2I3FWG4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Tumor necrosis factor ligand superfamily member {ECO:0000256|PIRNR:PIRNR038013};
GN Name=TNFSF11 {ECO:0000313|Ensembl:ENSNLEP00000025369.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000025369.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000025369.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000025369.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|PIRNR:PIRNR038013}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670, ECO:0000256|PIRNR:PIRNR038013}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01053140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01053141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01053142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01053143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01053144; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01053145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01053146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01053147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003270075.1; XM_003270027.1.
DR AlphaFoldDB; A0A2I3FWG4; -.
DR STRING; 61853.ENSNLEP00000025369; -.
DR Ensembl; ENSNLET00000045410.1; ENSNLEP00000025369.1; ENSNLEG00000031302.1.
DR GeneID; 100599838; -.
DR KEGG; nle:100599838; -.
DR CTD; 8600; -.
DR GeneTree; ENSGT01070000253816; -.
DR InParanoid; A0A2I3FWG4; -.
DR OMA; RAQMDPT; -.
DR OrthoDB; 5305009at2759; -.
DR Proteomes; UP000001073; Chromosome 5.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045453; P:bone resorption; IEA:Ensembl.
DR GO; GO:0055074; P:calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0007254; P:JNK cascade; IEA:Ensembl.
DR GO; GO:0060749; P:mammary gland alveolus development; IEA:Ensembl.
DR GO; GO:0033598; P:mammary gland epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0002548; P:monocyte chemotaxis; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0001503; P:ossification; IEA:Ensembl.
DR GO; GO:0036035; P:osteoclast development; IEA:Ensembl.
DR GO; GO:0002158; P:osteoclast proliferation; IEA:Ensembl.
DR GO; GO:0038001; P:paracrine signaling; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0045780; P:positive regulation of bone resorption; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0051466; P:positive regulation of corticotropin-releasing hormone secretion; IEA:Ensembl.
DR GO; GO:0071848; P:positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling; IEA:Ensembl.
DR GO; GO:0071812; P:positive regulation of fever generation by positive regulation of prostaglandin secretion; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0034112; P:positive regulation of homotypic cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:2001206; P:positive regulation of osteoclast development; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0042327; P:positive regulation of phosphorylation; IEA:Ensembl.
DR GO; GO:0050870; P:positive regulation of T cell activation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0044691; P:tooth eruption; IEA:Ensembl.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR017355; TNF_ligand_10/11.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11471:SF3; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 11; 1.
DR Pfam; PF00229; TNF; 1.
DR PIRSF; PIRSF038013; TNF10_TNF11; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|PIRNR:PIRNR038013};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038013};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 49..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 166..313
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..41
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 317 AA; 35459 MW; 226DB3E90D436BC3 CRC64;
MRRASRDYTK YLRGSEEMGG GPGAPHEGPL HAPPPRAPHQ PPAASRSMFV ALLGLGLGQV
VCSVALFLYF RAQMDPNRIS EDGTHCIYRI LRLHENADFQ DTTLESQDAK LIPDSCRRIK
QAFQGAVQKE LQHIVGSQHI RAEKAMVDGS WLDLAKRSKL EAQPFAHLTI NATDIPSGSH
KVSLSSWYHD RGWAKISNMT FSNGKLIVNQ DGFYYLYANI CFRHHETSGD LATEYLQLMV
YVTKTSIKIP SSHTLMKGGS TKYWSGNSEF HFYSINVGGF FKLRSGEEIS VEVSNPSLLD
PDQDATYFGA FKVRDID
//
