ID A0A2I3FX59_NOMLE Unreviewed; 1564 AA.
AC A0A2I3FX59;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=TTBK2 {ECO:0000313|Ensembl:ENSNLEP00000025392.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000025392.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000025392.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000025392.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; ADFV01034270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01034271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01034272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01034273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01034274; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01034275; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01034276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01034277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01034278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01034279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 61853.ENSNLEP00000025392; -.
DR Ensembl; ENSNLET00000055716.1; ENSNLEP00000025392.1; ENSNLEG00000004576.3.
DR GeneTree; ENSGT00940000160367; -.
DR InParanoid; A0A2I3FX59; -.
DR Proteomes; UP000001073; Chromosome 6.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR11909; CASEIN KINASE-RELATED; 1.
DR PANTHER; PTHR11909:SF451; TAU-TUBULIN KINASE 2; 1.
DR Pfam; PF00038; Filament; 2.
DR Pfam; PF16208; Keratin_2_head; 1.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 1..258
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 340..571
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 670..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 994..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1372..1408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1436..1564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 508..542
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1372..1394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1436..1453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1454..1468
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1504..1532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1539..1564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1564 AA; 173490 MW; 8F85BE18FD059E97 CRC64;
MESLSKDWGW GLWRNLRCLG HAHQGKCCTE GGISSTTKTS SENGSCWKDH VCRFIGCGRN
DRFNYVVMQL QGRNLADLRR SQSRGTFTMS TTLRLGRQIL ESIESIHSVG FLHRDIKPSN
FAMGRFPSTC RKCYMLDFGL ARQFTNSCGD VRPPRAVAGF RGTVRYASIN AHRNREMGRH
DDLWSLFYML VEFVVGQLPW RKIKDKEQVG SIKERYDHRL MLKHLPPEFS IFLDHISSLD
YFTKPDYQVT IFVSSKSYKV STSGPQAFNS LSYTSGPGAC ISSLSFFRMG SSSFWGGLSA
EYGGAGGASG GITAVTVNQS LLSPLNLEVD LNIQAVRTQE EKQIKTLNNK FASFIDKVRF
LEQQNKMLET KWSLVQQQKM ARSNMDNMFE SYINSLRWQR RLWLEAELGS MHRLVEDFRN
KYEDEISMCT EMENEFVLIN GGFSPEGLTA EISFFRQLYE EEIRSCSTRS RIHLWCCSWT
TAASWTWAAS SLRSRGTGFP GGRHADTKQR GELAIKDADA KLSELEAALQ LASQDMAQQL
HEYQELMKVK LALDIKIATY RKLLEGEESW LESGMQNMSI HMKTTSSYAG GQSLLLTSVF
DNSIKTFGVI ESDPFDWEKT GNDGSLTTTT TSTTPQLHTR LTPAAVGIAN ATPIPGDLLR
ENTDEVFPDE QLSDGENGIP VGVSPDKLPG SLGHPRPQEK DVWEEMDANK NKIKLGICKA
ATEEENSHGQ ANGLLNAPSL GSPIRVRSEI TQPDRDIPLV RKLRSIHSFE LEKRLTLEPK
PDTDKFLETC LEKMQKDTSA GKESILPALL HKPCVPAASR TDHIWHYDEE YLPDASKPAS
ANTPEQADGG GSNGFIAVNL SSCKQEIDSK EWVIVDKEQD LQDFRTNEAV GHKTTGSPSD
EEPEVLQVLE ASPQDEKLQL GPWAENDHLK KETSGVVLAL SAEGPPTAAS EQYTDRLELQ
PGAASQFIAA TPTSLMEAQA EGPLTAITIP RPSVASTQST SGSFHYGQQP EKKDLQPMEP
TVELYSPREN FSGLVVTEGE PPSGGSRTDL GLQIDHTGRD MLPNIRESNK SQDLGPKELP
DHNRLVVREF ENLPGETEEK SILLESDNED EKLSRGQHCI EISSLPGDLV IVEKDHSATT
EPLDVTKTQT FSVVPNQDKN NEIMKLLTVG TSEISSRDID PHVEGQIGQV AEMQKNKISK
DDDIMSEDLP GHQGDLSTFL HQEGKREKIT PRNGELFHCV SENEHGAPTR KDMVRSSFVT
RHSRIPVLAQ EIDSTLESSS PVSAKEKLLQ KKAYQPDLVK LLVERRQFKS FLGDLSSASD
KLLEEKLATV PAPFCEEEVL TPFSRLTVDS HLSRSAEDSF LSPIISQSRK SKIPRPVSWV
NTDQVNSSTS SQFFPRPPPG KPPTRPGVEA RLRRYKVLGS SNSDSDLFSR LAQILQNGSQ
KPRSTTQCKS PGSPHNPKTP PKSPVVPRRS PSASPRSSSL PRTSSSSPSR AGRPHHDQRS
SSPHLGRSKS PPSHSGSSSS RRSCQQEHCK PSKNGLKGSG SLHHHSASTK TPPGKSKPAS
KLSR
//
