ID A0A2I3FXI4_NOMLE Unreviewed; 875 AA.
AC A0A2I3FXI4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Solute carrier family 4 member 9 {ECO:0000313|Ensembl:ENSNLEP00000025450.1};
GN Name=SLC4A9 {ECO:0000313|Ensembl:ENSNLEP00000025450.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000025450.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000025450.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000025450.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993}.
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DR EMBL; ADFV01033237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01033238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3FXI4; -.
DR Ensembl; ENSNLET00000036405.1; ENSNLEP00000025450.1; ENSNLEG00000009225.2.
DR GeneTree; ENSGT00940000160970; -.
DR Proteomes; UP000001073; Chromosome 2.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022853; F:active monoatomic ion transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR GO; GO:0098660; P:inorganic ion transmembrane transport; IEA:UniProt.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF52; ANION EXCHANGE PROTEIN 4; 1.
DR Pfam; PF07565; Band_3_cyto; 2.
DR Pfam; PF00955; HCO3_cotransp; 2.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 659..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 720..742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..162
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 180..305
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 353..540
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT DOMAIN 562..783
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..855
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 875 AA; 96028 MW; 2323834C7A5E29B2 CRC64;
MEMKLPGQEG FEASSAPRNI PSGELDSNPD PGTGPSPDGP SDTDSKELGV PKDPLLFIQL
NELLGWPQAL EWRETGRWVL FEEKLEVAAG RWSAPHVPTL ALPSLQKLRS LLAEGLVLLD
CPAQSLLELV EQVTRVESLS PELRGQLQAL LLQRPQHYNQ TTGTRPCWGS THPRKASNNE
EAPLREQCQN PLRQKLPPGA EAGTVLAGEL GFLAQPLGAF VRLRDPVVLG SLTEVSLPSR
FFCLLLGPRM LGKGYHEMGR AAAVLLSDPQ FQWSVRRASN LHDLLAALDA FLEEVTVLPP
GRWDPTARIP PPKCLPSQHK RSEGPAVPRL TSAEDRHRHG PHAPSPELQR TGRLFGGLIQ
DVRRKVPWYP SDFFDALHLQ CFSAVLYIYL ATVTNAITFG GLLGDATDGA QGVLESFLGT
AVAGAAFCLM AGQPLTILSS TGPVLVFERL LFSFSRNYSL DYLPFRLWVG IWVATFCLVL
VATEASVLVR YFTRFTEEGF CALISLIFIY DAVGKMLNLT HTYPIQKPGS SAYGCLCQYP
GPGGNESQWI RTRPKDRDDI VSMVRKGLSD FSSVLAILLG CGLDAFLGLA TPKLMVPREF
KPTLSGRGWL VSPFGANPWW WSVAAALPAL LLSILIFMDQ QITAVILNRV EYRLQKGAGF
HLDLFCVAVL MLLTSALGLP WYVSATVISL AHMDSLRRES RACAPGGAPQ LPGEQRLTGL
VVFILTGASI FLAPVLKVSL LYKPGSGSFT KRVKLLLMPA KHQPDLLLLR HVPLTRVHLF
TAIQLACLGL LWIIKSTPAA IVFPLMLLGL VGVRKALERV FSPQELFWLD ELMPEEESSI
PEKGLEPEHS FSGSDSEDSE LMYQPKAPEI NISVN
//
