ID A0A2I3FZD0_NOMLE Unreviewed; 138 AA.
AC A0A2I3FZD0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Histone H3-like centromeric protein A {ECO:0000256|ARBA:ARBA00044194};
DE AltName: Full=Centromere protein A {ECO:0000256|ARBA:ARBA00044278};
GN Name=CENPA {ECO:0000313|Ensembl:ENSNLEP00000025690.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000025690.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000025690.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000025690.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the histone H3 family.
CC {ECO:0000256|ARBA:ARBA00010343}.
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DR EMBL; ADFV01061161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01061162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003270664.1; XM_003270616.3.
DR AlphaFoldDB; A0A2I3FZD0; -.
DR STRING; 61853.ENSNLEP00000025690; -.
DR Ensembl; ENSNLET00000036951.1; ENSNLEP00000025690.1; ENSNLEG00000034937.1.
DR GeneID; 100597561; -.
DR KEGG; nle:100597561; -.
DR CTD; 1058; -.
DR GeneTree; ENSGT01100000263514; -.
DR InParanoid; A0A2I3FZD0; -.
DR OMA; CQSFSRE; -.
DR OrthoDB; 2913278at2759; -.
DR Proteomes; UP000001073; Chromosome 19.
DR GO; GO:0043505; C:CENP-A containing nucleosome; IEA:Ensembl.
DR GO; GO:0000779; C:condensed chromosome, centromeric region; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005721; C:pericentric heterochromatin; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0034080; P:CENP-A containing chromatin assembly; IEA:Ensembl.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl.
DR GO; GO:0051382; P:kinetochore assembly; IEA:Ensembl.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:Ensembl.
DR GO; GO:0071459; P:protein localization to chromosome, centromeric region; IEA:Ensembl.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR000164; Histone_H3/CENP-A.
DR PANTHER; PTHR45810:SF14; HISTONE H3-LIKE CENTROMERIC PROTEIN A; 1.
DR PANTHER; PTHR45810; HISTONE H3.2; 1.
DR Pfam; PF00125; Histone; 1.
DR PRINTS; PR00622; HISTONEH3.
DR SMART; SM00428; H3; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR PROSITE; PS00959; HISTONE_H3_2; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 10..131
FT /note="Histone H2A/H2B/H3"
FT /evidence="ECO:0000259|Pfam:PF00125"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 138 AA; 15837 MW; 0163A574E21F2BEE CRC64;
MGPRRRIRKP EAPRRRSPSP TPGPSRRGPS LGASSRQHGW RRQGWLKEIR KLQKSTHLLI
RKLPFSRLAR EICVKFTRGV DFNWQAQALL ALQEAAEAFL VHLFEDAYLL TLHAGRVTLF
PKDVQLARRI RGLEEGLG
//
