ID A0A2I3G015_NOMLE Unreviewed; 938 AA.
AC A0A2I3G015;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=5'-3' exoribonuclease {ECO:0000256|PIRNR:PIRNR037239};
DE EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR037239};
GN Name=XRN2 {ECO:0000313|Ensembl:ENSNLEP00000025790.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000025790.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000025790.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000025790.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Possesses 5'->3' exoribonuclease activity. May promote
CC termination of transcription by RNA polymerase II.
CC {ECO:0000256|PIRNR:PIRNR037239}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family. XRN2/RAT1
CC subfamily. {ECO:0000256|ARBA:ARBA00006994,
CC ECO:0000256|PIRNR:PIRNR037239}.
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DR EMBL; ADFV01042712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01042713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01042714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01042715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01042716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01042717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3G015; -.
DR Ensembl; ENSNLET00000057358.1; ENSNLEP00000025790.1; ENSNLEG00000009991.2.
DR GeneTree; ENSGT00670000098098; -.
DR Proteomes; UP000001073; Chromosome 13.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-UniRule.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 3.40.50.12390; -; 2.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR017151; Xrn2/3/4.
DR PANTHER; PTHR12341:SF77; 5'-3' EXORIBONUCLEASE 2; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF037239; Exonuclease_Xrn2; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR037239};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR037239};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|PIRNR:PIRNR037239};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR037239};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1..254
FT /note="Xrn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03159"
FT DOMAIN 314..774
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT REGION 396..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..496
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 938 AA; 107323 MW; FDD6BFC2A73DDD51 CRC64;
MGVPAFFRWL SRKYPSIIVN CVEEKPKECN GVKIPVDASK PNPNDVEFDN LYLDMNGIIH
PCTHPEDKPA PKNEDEMMVA IFEYIDRLFS IVRPRRLLYM AIDGVAPRAK MNQQRSRRFR
ASKEGMEAAV EKQRVREEIL AKGGFLPPEE IKERFDSNCI TPGTEFMDNL AKCLRYYIAD
RLNNDPGWKN LTVILSDASA PGEGEHKIMD YIRRQRAQPN HDPNTHHCLC GADADLIMLG
LATHEPNFTI IREEFKPNKP KPCGLCNQFG HEVKDCEGLP REKKGKVRTL RCIKYLTYIY
LERELTMASL PFTFDVERSI DDWVFMCFFV GNDFLPHLPS LEIRENAIDR LVNIYKNVVH
KTGGYLTESG YVNLQRVQMI MLAVGEVEDS IFKKRKDDED SFRRRQKEKR KRMKRDQPAF
TPSGILTPHA LGSRNSPGSQ VASNPRQAAY EMRMQNNSSP SISPNTSFTS DGSPSPIGGI
KRKAEDSDSE PEPEDNVRLW EAGWKQRYYK NKFDVDAADE KFRRKVVQSY VEGLCWVLRY
YYQGCASWKW YYPFHYAPFA SDFEGIADMP SDFEKGTKPF KPLEQLMGVF PAASGNFLPP
SWRKLMSDPD SSIIDFYPED FAIDLNGKKY AWQGVALLPF VDERRLRAAL EEVYPDLTPE
ETRRNSLGGD VLFVGKHHPL HDFILELYQT GSTEPVDVPP ELCHGIQGRF SLDEEAILPD
QIVCSPVPML RDLTQNTVVS INFKDPQFAE DYIFKAVMLP GARKPAAVLK PSDWEKSSNG
RQWKPQLGFN RDRRPVHLDQ AAFRTLGHVM PRGSGTGIYS NAAPPPATYQ GNLYRPLLRG
QAQIPKLMSN MRPQDSWRGP PPLFQQQRFD RGVGAEPLLP WNRMLQTQNA AFQPNQYQML
AGPGGYPPRR DDRGGRQGYP REGRKYPLPP PSGRYNWN
//