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Database: UniProt
Entry: A0A2I3G1M9_NOMLE
LinkDB: A0A2I3G1M9_NOMLE
Original site: A0A2I3G1M9_NOMLE 
ID   A0A2I3G1M9_NOMLE        Unreviewed;       717 AA.
AC   A0A2I3G1M9;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   08-MAY-2019, entry version 8.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000026046};
GN   Name=VAV1 {ECO:0000313|Ensembl:ENSNLEP00000026046};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000026046, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000026046, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000026046}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   EMBL; ADFV01133656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01133657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01133658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01133659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01133660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01133661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01133662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01133663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01133664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01133665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSNLET00000048937; ENSNLEP00000026046; ENSNLEG00000032882.
DR   GeneTree; ENSGT00940000159125; -.
DR   Proteomes; UP000001073; Chromosome 10.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00029; C1; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd10405; SH2_Vav1; 1.
DR   CDD; cd11976; SH3_VAV1_2; 1.
DR   Gene3D; 1.10.418.10; -; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR022613; CAMSAP_CH.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR003096; SM22_calponin.
DR   InterPro; IPR028530; Vav1.
DR   InterPro; IPR035879; VAV1_SH2.
DR   InterPro; IPR035729; VAV1_SH3_2.
DR   PANTHER; PTHR45818:SF2; PTHR45818:SF2; 4.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF11971; CAMSAP_CH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   PRINTS; PR00888; SM22CALPONIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00253054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
KW   ECO:0000256|SAAS:SAAS01042643}; Zinc {ECO:0000256|SAAS:SAAS00253075}.
FT   DOMAIN        1    121       Calponin-homology (CH).
FT                                {ECO:0000259|PROSITE:PS50021}.
FT   DOMAIN      184    311       DH. {ECO:0000259|PROSITE:PS50010}.
FT   DOMAIN      409    458       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN      543    637       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   DOMAIN      654    714       SH3. {ECO:0000259|PROSITE:PS50002}.
SQ   SEQUENCE   717 AA;  82666 MW;  4A09DA0F945EF2E5 CRC64;
     MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL LPHAINLREV
     NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVSW ALEAQRPSFS
     SFPLTSTLSK LRAVRGQSDN DTVEEDEDLY DCVENEETEG DEIYEDLMRS EPVSMPPKMT
     EYDKRCCCLR EIQQTEEKYT DTLGSIQQHF LKPLQRFLKP QDIEIIFINI EDLLRVHTHF
     LKEMKDALGT PGAANLYQVF IKYKERFLVY GRYCSQVESA SKHLDRVAAA REDVQMKLEL
     QRVHFLLQPS QGSIKGLGRE VLASQAEEME KNRNGLALGL ARQECLIHPS RYAFLLDKAL
     LICKRRGDSY DLKDFVNLHS FQVRDDSSGD RDNKKVGSNI YPENAAANGH DFQMFSFEET
     TSCRACQMLL RGTFYQGYRC HRCRAPAHKE CLGRVPPCGR HGQDFPGTMK KDKLHRRAQD
     KKRNELGLPK MEVFQEYYGL PPPPGAIGPF LRLNPGDIVE LTKAEAEQNW WEGPPQDLSV
     HLWYAGPMER AGAESILANR SDGTFLVRQR VKDAAEFAIS IKYNVEVKHI KIMTAEGLYR
     ITEKKAFRGL TELVEFYQQN SLKDCFKSLD TTLQFPFKEP EKRTISKPAV GSTKYFGTAK
     ARYDFCARDR SELSLKEGDI IKILNKKGQQ GWWRGEIYGR VGWFPANYVE EDYSEYC
//
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