ID A0A2I3G1T6_NOMLE Unreviewed; 1904 AA.
AC A0A2I3G1T6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Bromodomain adjacent to zinc finger domain 2A {ECO:0000313|Ensembl:ENSNLEP00000026108.1};
GN Name=BAZ2A {ECO:0000313|Ensembl:ENSNLEP00000026108.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000026108.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000026108.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000026108.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR EMBL; ADFV01002392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01002393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01002394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01002395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003252853.2; XM_003252805.3.
DR Ensembl; ENSNLET00000052799.1; ENSNLEP00000026108.1; ENSNLEG00000017462.2.
DR GeneID; 100582288; -.
DR KEGG; nle:100582288; -.
DR CTD; 11176; -.
DR GeneTree; ENSGT00940000159490; -.
DR OrthoDB; 2912910at2759; -.
DR Proteomes; UP000001073; Chromosome 11.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd01397; HAT_MBD; 1.
DR CDD; cd15629; PHD_BAZ2A; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028940; PHD_BAZ2A.
DR InterPro; IPR028942; WHIM1_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF5; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2A; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15612; WHIM1; 1.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00384; AT_hook; 4.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 541..612
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 843..908
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 1675..1725
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1809..1879
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1173..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1231..1259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1329..1411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1733..1754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1768..1788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..707
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1346..1376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1904 AA; 211320 MW; 3D4221EBA05E833C CRC64;
MEMEANDHFN FTGLPPAPAA SGLKPSPSSG EGLYTNGSPM NFPQQGKSLN GDVNVNGLST
VSHTTTSGIL NSAPHSSSTS HLHHPSVAYD CLWNYSQYPS ANPGSNLKDP PLLSQFSGTQ
YPLNGILGGS RQPSSPSHNT NLRAGSQEFW ANGTQSPMGL NFDSQELYDS FPDQNFEVMP
NGPPSFFTSP QTSPMLGSSI QTFAPSQEVG SGIHPDEAAE KEMTSVVSEN GTGLVGSLEL
EEQPELKMCG YNGSVPSVES LHQEVSVLVP DPTVSCLDDP SHLPDQLEDT PILSEDSLEP
FNSLAPEPVS GGLYGIDDTE LMGAEDKLPL EDSPVISALD CPSLNNATAF SLLADDSQTS
TSIFVSPTSP PVLGESVLQD NSFDLNNGSD TEQEEMESQS SDFPPSLTQP APDQSSTIQL
HPATSPAVSP TTSPAVSLVV SPAASPEISP EVCPAASTLV PPAVFSVVSP ASSAVSSEVP
LTASVTSPKA SPVTSPAAAF PTASPANKDV SSFLETTADL EEITGEGLTT SGSGDVMRRR
IATPEEVRLP LQHGWRREVR IKKGSHRWQG ETWYYGPCGK RMKQFPEVIK YLSRNVVHSV
RREHFSFSPR MPVGDFFEER DTPEGLQWVQ LSAEEIPSRI QAITGKRGRP RNTEKAKTKE
VPKVKRGRGR PPKVKITELL NKTDNRPLKK LEAQETLNEE DKAKIAKSKK KMRQKVQRGE
CQSTIQGQAR NKRKQETKSL KQKEAKKKSK AEKEKGKTKQ EKLKEKVKRE KKEKVKMKEK
EEVTKAKPAC KADKTLATQR RLEERQRQQM ILEEMKKPTE DMCLTDHQPL PDFSRVPGLT
LPSGAFSDCL TIVEFLHSFG KVLGFDPAKD VPSLGVLQEG LLCQGDSLGE VQDLLVRLLK
AALHDPGLPS YCQSLKILGE KVSEIPLTRD NVSEILRCFL MAYGVEPALC DRLRTQPFQA
QPPQQKAAVL AFLVHELNGS TLIINEIDKT LESMSSYRKN KWIVEGRLRR LKTVLAKRTG
RSEIEMEGPE ECLGRRRSSR IMEETSGMEE EEEEESIAAV HGRRGRRDGE VDATASSIPE
LERQIEKLSK RQLFFRKKLL HSSQMLRAVS LGQDRYRRRY WVLPYLAGIF VEGTEGNLVP
EDVIKKETDS LKVAAHASLN PALFSMKMEL AGSNTTANSP ARARGRPRKT KPGSMQPRHL
KSPVRGQDSE QPQAQLQPEA QLHALAQPQP QLQLQLQSHP QSHKGFLEQE GSPLSLGQSQ
HDLSQSAFLS WLSQTQSHSS LLSSSVLTPD SSPGKLDPAP SQPPEEPEPD EAESSPDPQA
LWFNISAQMP CNAAPTPPPA VSEDQPTPSP QQLASSKPMN RPSAANRCSP VQFSSTPLAG
LAPKRRAGDP GEMPQSPTGL GQPKRRGRPP SKFFKQMEQR YLTQLTAQPV PPEMCSGWWW
IRDPETLDAM LKALHPRGIR EKALHKHLNK HKDFLQEVCL RPSADPIFEP RQLPAFQEGI
MSWSPKEKTY ETDLAVLQWV EELEQRVIMS DLQIRGWTCP SPDSTREDLA YCEHLSDSQE
DITWRGRGRE GLAPQRKTTN PLDLAVMRLA ALEQNVERRY LREPLWPTHE VVLEKALLST
PNGAPEGTTT EISYEITPRI RVWRQTLERC RSAAQVCLCL GQLERSIAWE KSVNKVTCLV
CRKGDNDEFL LLCDGCDRGC HIYCHRPKME AVPEGDWFCT VCLAQQVEGE FTQKPGFPKR
GQKRKSGYSL NFSEGDGRRR RVLLRGRESP AAGPRYSEEG LSPSKRRRLS MRNHHSDLTF
CEIILMEMES HDAAWPFLEP VNPRLVSGYR RIIKNPMDFS TMRERLLRGG YTSSEEFAAD
ALLVFDNCQT FNEDDSEVGK AGHIMRRFFE SRWEEFYQGK QANL
//
