ID A0A2I3G2F8_NOMLE Unreviewed; 746 AA.
AC A0A2I3G2F8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Transient receptor potential cation channel subfamily C member 7 {ECO:0000313|Ensembl:ENSNLEP00000026333.1};
GN Name=TRPC7 {ECO:0000313|Ensembl:ENSNLEP00000026333.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000026333.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000026333.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000026333.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; ADFV01032889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003266466.1; XM_003266418.2.
DR AlphaFoldDB; A0A2I3G2F8; -.
DR Ensembl; ENSNLET00000046392.1; ENSNLEP00000026333.1; ENSNLEG00000008430.3.
DR GeneID; 100581264; -.
DR CTD; 57113; -.
DR GeneTree; ENSGT01060000248588; -.
DR OrthoDB; 5406916at2759; -.
DR Proteomes; UP000001073; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF9; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 269..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 198..260
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 86283 MW; 8C32E3E80C251929 CRC64;
MLRSSTFKNM QRRHTTLREK GRRQAIRGPA YMFNEKGTSL TPEEERFLDS AEYGNIPVVR
KMLEESKTLN FNCVDYMGQN ALQLAVGNEH LEVTELLLKK ENLARVGDAL LLAISKGYVR
IVEAILNHPA FAQGQRLTLS PLEQELRDDD FYAYDEDGTR FSHDITPIIL AAHCQEYEIV
HILLLKGARI ERPHDYFCKC NECTEKQRKD SFSHSRSRMN AYKGLASAAY LSLSSEDPVL
TALELSNELA RLANIETEFK LGRTLRSPFM KFVAHAVSFT IFLGLLVVNA SDRFEGVKTL
PNETFTDYPK QIFRVKTTQF SWTEMLIMKW VLGMIWSECK EIWEEGPREY VLHLWNLLDF
GMLSIFVASF TARFMAFLKA TEAQLYVDQH VQDNTLHNVS LPPEVAYFTY ARDKWWPSDP
QIISEGLYAI AVVLSFSRIA YILPANESFG PLQISLGRTV KDIFKFMVIF IMVFVAFMIG
MFNLYSYYRG AKYNPAFTTV EESFKTLFWS IFGLSEVISV VLKYDHKFIE NIGYVLYGVY
NVTMVVVLLN MLIAMINNSY QEIEEDADVE WKFARAKLWL SYFDEGRTLP APFNLVPSPK
SFYYLIMRIK MCLIKLCKSK AKSCENDLEM GMLNSKFKKT RYQAGMRNSE NLTANNTFSK
PTRYQKIMKR LIKRYVLKAQ VDRENDEVNE GELKEIKQDI SSLRYELLEE KSQATGELAD
LIQQLSEKFG KNLNKDHLRV NKGKDI
//
