ID A0A2I3G3E1_NOMLE Unreviewed; 559 AA.
AC A0A2I3G3E1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Rap1 GTPase-GDP dissociation stimulator 1 {ECO:0000313|Ensembl:ENSNLEP00000026666.1};
GN Name=RAP1GDS1 {ECO:0000313|Ensembl:ENSNLEP00000026666.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000026666.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000026666.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000026666.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}.
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DR EMBL; ADFV01177102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012354927.1; XM_012499473.1.
DR AlphaFoldDB; A0A2I3G3E1; -.
DR Ensembl; ENSNLET00000037647.1; ENSNLEP00000026666.1; ENSNLEG00000014011.3.
DR GeneID; 100593839; -.
DR CTD; 5910; -.
DR GeneTree; ENSGT00390000014293; -.
DR OrthoDB; 2951120at2759; -.
DR Proteomes; UP000001073; Chromosome 9.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR040144; RAP1GDS1.
DR PANTHER; PTHR10957; RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1; 1.
DR PANTHER; PTHR10957:SF2; RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1; 1.
DR Pfam; PF00514; Arm; 4.
DR SMART; SM00185; ARM; 5.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50176; ARM_REPEAT; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 90..132
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 309..341
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 559 AA; 61078 MW; 1BC4D7B4EBADC6BF CRC64;
MADNLSDTLK KLKITAVDKT EDSLEGCLDC LLQALAQNNT ETSEKIQASG ILQLFASLLT
PQSSCKAKVA NIIAEVAKNE FMRIPCVDAG LISPLVQLLN SKDQEVLLQT GRALGNICYD
SHSLQAQLIN MGVIPTLVKL LGIHCQNAAL TEMCLVAFGN LAELESSKEQ FASTNIAEEL
VKLFKKQIEH DKREMIFEVL APLAENDAIK LQLVEAGLVE CLLEIVQQKV DSDKEDDITE
LKTGSDLMVL LLLGDESMQK LFEGGKGSVF QRVLSWIPSN NHQLQLAGAL AIANFARNDG
NCIHMVDNGI VEKLMDLLDR HVEDGNVTVQ HAALSALRNL AIPVINKAKM LSAGVTEAVL
KFLKSEMPPV QFKLLGTLRM LIDAQAEAAE QLGKNVKLVE RLVEWCEAKD HAGVMGESNR
LLSALIRHSK SKDVIKTIVQ SGGIKHLVTM ATSEHVIMQN EALVALALIA ALELGTAEKD
LESAKLVQIL HRLLADERSA PEIKYNSMVL ICALMGSESL HKEVQDLAFL DVVSKLRSHE
NKSVAQQASL TEQRLTVES
//
