ID A0A2I3G3P1_NOMLE Unreviewed; 631 AA.
AC A0A2I3G3P1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN Name=ITPR1 {ECO:0000313|Ensembl:ENSNLEP00000026747.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000026747.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000026747.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000026747.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU368044}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|RuleBase:RU368044}.
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DR EMBL; ADFV01025715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3G3P1; -.
DR Ensembl; ENSNLET00000039666.1; ENSNLEP00000026747.1; ENSNLEG00000003382.3.
DR GeneTree; ENSGT00940000155071; -.
DR Proteomes; UP000001073; Chromosome 21.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR13715:SF52; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1; 1.
DR PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF01365; RYDR_ITPR; 1.
DR PRINTS; PR00779; INSP3RECEPTR.
DR SMART; SM00472; MIR; 3.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50919; MIR; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|RuleBase:RU368044};
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|RuleBase:RU368044};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|RuleBase:RU368044}.
FT DOMAIN 85..141
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 148..212
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 218..274
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
SQ SEQUENCE 631 AA; 71448 MW; B45D65D65ED2A929 CRC64;
MRVTLDEAGN EGSWFYIQPF YKLRSIGDSV VIGDKVVLNP VNAGQPLHAS SHQLVDNPGC
NEVNSVNCNT SWKIVLFMKW SDNKDDILKG GDVVRLFHAE QEKFLTCDEH RKKQHVFLRT
TGRQSATSAT SSKALWEVEV VQHDPCRGGA GYWNSLFRFK HLATGHYLAA EVDADQDASR
SRLRNAQEKM VYSLVSVPEG NDISSIFELD PTTLRGGDSL VPRNSYVRLR HLCTNTWVHS
TNIPIDKEEE KPVMLKIGTS PVKEDKEAFA IVPVSPAEVR DLDFANDASK VLGSIAGKLE
KGTITQNERR SVTKLLEDLV YFVTGGTNSG QDVLEVVFSK PNRERQKLMR EQNILKQIFK
LLQAPFTDCG DGPMLRLEEL GDQRHAPFRH ICRLCYRVLR HSQQDYRKNQ EYIAKQFGFM
QKQIGYDVLA EDTITALLHN NRKLLEKHIT AAEIDTFVSL VRKNREPRFL DYLSDLCVSM
NKSIPVTQEL ICKAVLNPTN ADILIETKLV LSRFEFEGVS STGENALEAG EDEEEVWLFW
RDSNKEIRSK SVRELAQDAK EGQKEDRDVL SYYSCHDSFY VYLSACFPAC TCLTSAGHLL
GPQCLLVSSS KTCQSCHLKG REGEERREVN Q
//
