ID A0A2I3G435_NOMLE Unreviewed; 1271 AA.
AC A0A2I3G435;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Dynactin subunit 1 {ECO:0000256|ARBA:ARBA00016574};
GN Name=DCTN1 {ECO:0000313|Ensembl:ENSNLEP00000026827.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000026827.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000026827.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000026827.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynactin 150 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00011010}.
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DR EMBL; ADFV01045809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01045810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004090471.1; XM_004090423.2.
DR AlphaFoldDB; A0A2I3G435; -.
DR Ensembl; ENSNLET00000034685.1; ENSNLEP00000026827.1; ENSNLEG00000000385.3.
DR GeneTree; ENSGT00940000155378; -.
DR Proteomes; UP000001073; Chromosome 14.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR022157; Dynactin.
DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR PANTHER; PTHR18916:SF6; DYNACTIN SUBUNIT 1; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF12455; Dynactin; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 48..90
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 945..1036
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1271 AA; 140875 MW; 7327B17B44E78028 CRC64;
MAQSKRHVYS RTPSGSRMSV EASARPLRVG SRVEVIGKGH RGTVAYVGAT LFATGKWVGV
ILDEAKGKND GTVQGRKYFT CDEGHGIFVR QSQIQVFEDG ADTTSPETPD SSASKVLKRE
GTDTTAKTSK LAPTARKTTA RRPKPTRPAS TGVAGASSSL GPSGSASAGE LSSSEPSTPA
QTPLAAPIIP TPVLTSPGAV PPLPSPSKEE EGLRAQVRDL EEKLETLRLK RAEDKAKLKE
LEKHKIQLEQ VQEWKSKMQE QQADLQRRLK EARKEAKEAL EAKERYMEEM ADTADAIEMA
TLDKEMAEER AESLQQEVEA LKERVDELTT DLEILKAEIE EKGSDGAASS YQLKQLEEQN
ARLKDALVRM RDLSSSEKQE HVKLQKLMEK KNQELEVVRQ QRERLQEELS QAESTIDELK
EQVDAALGAE EMVEMLTDRN LNLEEKVREL RETVGDLEAM NEMNDELQEN ARETELELRE
QLDMAGARVR EAQKRVEAAQ ETVADYQQTI KKYRQLTAHL QDVNRELTNQ QEASVERQQQ
PPPETFDFKI KFAETKAHAK AIEMELRQME VAQANRHMSL LTAFMPDSFL RPGGDHDCVL
VLLLMPRLIC KAELIRKQAQ EKFELSENCS ERPGLRGAAG EQLSFAAGLV YSLSLLQATL
HRYEHALSQC SVDVYKKVGS LYPEMSAHER SLDFLIELLH KDQLDETVNV EPLTKAIKYY
QHLYSIHLAE QPEDCTMQLA DHIKFTQSAL DCMSVEVGRL RAFLQGGQEA TDIALLLRDL
ETSCSDIRQF CKKIRRRMPG TDAPGIPAAL AFGPQVSDTL LDCRKHLTWV VAVLQEVAAA
AAQLIAPLAE NEGLPVAALE ELAFKASEQI YGIPSSSPYE CLRQSCNILI STMNKLATAM
QEGEYDAERP PSKPPPVELR AAALRAEITD AEGLGLKLED RETVIKELKK SLKIKGEELS
EANVRLSLLE KKLDSAAKDA DERIEKVQTR LEETQALLRK KEKEFEETMD ALQADIDQLE
AEKAELKQRL NSQSKRTIEG LRGPPPSGIA TLVSGIAGEE QQRGAVPGQA PGSVPGPGLV
KDSPLLLQQI SAMRLHISQL QHENSILKGA QMKASLASLP PLHVAKLSHE GPGSELPAGV
LYRKTSQLLE TLNQLSTHTH VVDITRTSPA AKSPSAQLME QVAQLKSLSD TIEKLKDEVL
KETVSQRPGA TVPTDFATFP SSAFLRAKEE QQDDTVYMGK VTFSCAAGLG QRHRLVLTQE
QLHQLHSRLI S
//