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Database: UniProt
Entry: A0A2I3G6B9_NOMLE
LinkDB: A0A2I3G6B9_NOMLE
Original site: A0A2I3G6B9_NOMLE 
ID   A0A2I3G6B9_NOMLE        Unreviewed;      4773 AA.
AC   A0A2I3G6B9;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 5.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSNLEP00000027152};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSNLEP00000027152};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000027152, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000027152, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000027152}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; ADFV01073594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSNLET00000052432; ENSNLEP00000027152; ENSNLEG00000010690.
DR   GeneTree; ENSGT00940000155507; -.
DR   Proteomes; UP000001073; Chromosome 6.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 3.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4099   4123       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4329   4349       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4397   4416       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4522   4540       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4583   4604       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4663   4686       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       95    150       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      157    202       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    395       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      542    753       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      957   1153       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1199   1411       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3835   3870       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      454    474       {ECO:0000256|SAM:Coils}.
FT   COILED     3161   3181       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4773 AA;  541383 MW;  68A79C39FD2D9FA8 CRC64;
     MARCSEGGRL QLEDEVVLQC IATIHKEQRK FCLAAEGLGN RLCFLEPTSE AKYIPPDLCV
     CNFVLEQSLS VRALQEMLAN TGENGGEGAA QGGGHRTLLY GHAVLLRHSF SGMYLTCLTT
     SRSQTDKLAF DVGLREHATG EACWWTIHPA SKQRSEGEKV RIGDDLILVS VFSERYLHLS
     VSNGNIQVDA SFMQTLWNVH PTCSGSSIEE GYLLGGHVVR LFHGHDECLT IPSTDQNDSQ
     HRRIFYEAGG AGTRARSLWR VEPLRISWSG SNIRWGQAFR LRHLTTGHYL ALTEDQGLIL
     QDRAKSDTKS TAFSFRASKE LKEKLDSSHK RDIEGMGVPE IKYGDSVCFV QHIASGLWVT
     YKAQDAKTSR LGPLKRKVIL HQEGHMDDGL TLQRCQREES QAARIIRNTT ALFSQFVSGN
     NRTAAPITLP IEEVLQTLQD LIAYFQPPEE EMRHEDKQNK LRSLKNRQNL FKEECLQTLV
     FSALIRGNRN NCAQFSNNLD WLISKLDRLE SSSGILEVLH CILTESPEAL NLIAEGHIKS
     IISLLDKHGR NHKVLDILCS LCLCNGIAVR ANQNLICDNL LPRRNLLLQT RLINDVTSIR
     PNIFLGVAEG SAQYKKWYFE LIIDQVDPFL TAEPTHLRVG WASSSGYAPY PGGGEGWGGN
     GVGDDLYSYG FDGLHLWSGR IPRAVASINQ HLLRSDDVVS CCLDLGVPSI SFRINGQPVQ
     GMFENFNTDG LFFPVMSFSA GVKVRFLMGG RHGEFKFLPP SGYAPCYEAL LPKEKMRLEP
     VKEYKRDADG VRDLLGTTQF LSQASFIPCP IDTSQVVLPP HLEKIRDRLA ENIHELWGMN
     KIELGWTFGK IRDDNKRQHP CLVEFSKLPE TEKNYNLQMS TETLKVGPVT VAFFAQHSYH
     VYMMSNGYKP APLDLSDVKL LPPQEILVDK LAENAHNVWA KDRIKQGWTY GIQQDLKNKR
     NPRLVPYALL DERTKKSNRD SLREAVRTFV GYGYNIEPSD QELADSAVEK VSIDKIRFFR
     VERSYAVRSG KWYFEFEVVT GGDMRVGWAR PGCRPDVELG ADDQAFVFEG NRGQRWHQGS
     GYFGRTWQPG DVVGCMINLD DASMIFTLNG ELLITNKGSE LAFADYEIEN GFVPICCLGL
     SQIGRMNLGT DASTFKFYTM CGLQEGFEPF AVNMNRDVAM WFSKRLPTFV NVPKDHPHIE
     VMRIDGTMDS PPCLKVTHKT FGTQNSNADM IYCRLSMPVE CHSSFSHSPC LDSEAFQKRK
     QMQEILSHTT TQCYYAIRIF AGQDPSCVWV GWVTPDYHLY SEKFDLNKNC TVTVTLGDER
     GRVHESVKRS NCYMVWGGDI VASSQRSNRS NVDLEIGCLV DLAMGMLSFS ANGKELGTCY
     QVEPNTKVFP AVFLQPTSTS LFQFELGKLK NAMPLSAAVF KIPQCPPRLD VQTIQPVLWS
     RMPNSFLKVE TERVSERHGW VVQCLEPLQM MALHIPEENR CVDILELCEQ EDLMRFHYHT
     LRLYSAVCAL GNSRVAYALC SHVDLSQLFY AIDNKYLPGL LRSGFYDLLI SIHLANAKER
     KLMMKNEYII PITSTTRNIR LFPDESKRHG LPGVGLRTCL KPGFRFSTPC FVVTGEDHQK
     QSPEIPLESL RTKALSMLTE AVQCSGAHIR DPVGGSVEFQ FVPVLKLIGT LLVMGVFDDD
     DVRQILLLID PSVFGEHSAG TEEGAEKEDV SQVEEKAVEA GEKAGKEAPV KGLLQTRLPE
     SVKLQMCELL SYLCDCELQH RVEAIVAFGD IYVSKLQANQ KFRYNELMQA LNMSAALTAR
     KTKEFRSPPQ EQINMLLNFQ LGENCPCPEE IREELYDFHE DLLLHCGVPL EEEEEEEEDT
     SWTGKLCALV YKIKGPPKPE KEQPTEEEER CPTTLKQLIS QTMICWAQED QIQDSELVRM
     MFNLLRRQYD SIGELLQALR KTYTISHTSV SDTINLLAAL GQIRSLLSVR MGKEEELLMI
     NGLGDIMNNK VFYQHPNLMR VLGMHETVME VMVNVLGTEK SQIAFPKMVA SCCRFLCYFC
     RISRQNQKAM FEHLSYLLEN SSVGLASPSM RGSTPLDVAA SSVMDNNELA LSLEEPDLEK
     VVTYLAGCGL QSCPMLLAKG YPDVSWNPIE GERYLSFLRF AVFVNSESVE ENASVVVKLL
     IRRPECFGPA LRGEGGNGLL AAMQGAIKIS ENPALDLPSQ GYKREVTEDD EEEEEIVHMG
     NAIMSFYSAL IDLLGRCAPE MHLIQTGKGE AIRIRSILRS LVPTEDLVGI ISIPLKLPSL
     NKDGSVSEPD MAANFCPDHK APMVLFLDRV YGIKDQTFLL HLLEVGFLPD LRASASLDTV
     SLSTAEAALA LNRYICSAVL PLLTRCAPLF AGTEHCTSLI DSTLQTIYRL SKGRSLTKAQ
     RDTIEECLLA ICNHLRPSML QQLLRRLVFD VPQLNEYCKM PLKLLTNHYE QCWKYYCLPS
     GWGSYGLAVE EELHLTEKLF WGIFDSLSHK KYDPDLFRMA LPCLSAIAGA LPPDYLDTRI
     TATLEKQISV DADGNFDPKP INTMNFSLPE KLEYIVTKYA EHSHDKWACD KSQSGWKYGI
     SLDENVKTHP LIRPFKTLTE KEKEIYRWPA RESLKTMLAV GWTVERTKEG EALVQQRENE
     KLRSVSQANQ GNSYSPAPLD LSNVVLSREL QGMVEVVAEN YHNIWAKKKK LELESKGGGS
     HPLLVPYDTL TAKEKFKDRE KAQDLFKFLQ VNGVIVSRGM KDMELDASSM EKRFAYKFLK
     KILKYVDSAQ EFIAHLEAIV SSGKTEKSPH DQEIKFFAKV LLPLVDQYFT NHRLYFLSSP
     LKPLSSSGYA SHKEKEMVAR LHLKDRLSGL RESQMIFFIL GSDSTTMVSC LHILAQTLDT
     RTVMKSGSEL VKAGLRAFFE NAAEDLEKTS ENLKLGKFTH SRTQIKGVSQ NINYTTVALL
     PILTSIFEHV TQHQFGMDLL LGDVQISCYH ILCSLYSLGT GKNIYVERQR PALGECLASL
     AAAIPVAFLE PTLNRYNLLS VFNTKTPRER SILGMPDTVE DMCPDIPQLE GLMKEINDLA
     ESGARYTEMP HVIEVILPML CNYLSYWWER GPENLPPSTG PCCTKVTSEH LSLILGNILK
     IINNNLGIDE ASWMKRIAVY AQPIISKARP DLLRSHFIPT LEKLKKKAVK TVQEEEQLKA
     DGKGDTQEAE LLILDEFAVL CRDLYAFYPM LIRYVDNNRS NWLKSPDADS DQLFRMVAEV
     FILWCKSHNF KREEQNFVIQ NEINNLAFLT GDSKSKMSKS GGQDQERKKT KRRGDLYSIQ
     TSLIVAALKK MLPIGLNMCT PGDQELISLA KSRYGHRDTD EEVREHLRNN LHLQEKSDDP
     AVKWQLNLYK DVLKSEEPFN PEKTVERVQR ISAAVFHLEQ VEQPLRSKKA VWHKLLSKQR
     KRAVVACFRM APLYNLPRHR SINLFLHGYQ RFWIETEEYS FEEKLVQDLA KSPKVEEEEE
     EETEKQPDPL HQIILYFSRN ALTERRSEPP SCQSGEDEEE DEDKEKTFEE KEMEKQKTLY
     QQARLHERGA AEMVLQMISA SKGEMSPMVV ETLKLGIAIL NGGNAGVQQK MLDYLKEKKD
     AGFFQSLSGL MQSCSVLDLN AFERQNKAEG LGMVTEEGTL IVRERGKFQF LNDEFTRDLF
     RFLQLLCEGH NSDFQNFLRT QMGNTTTVNV IISTVDYLLR LQESISDFYW YYSGKDIIDE
     SGQHNFSKAL AVTKQVFNSL TEYIQGPCIG NQQSLAHSRL WDAVVGFLHV FANMQMKLSQ
     SSKNSYLTSD MIAWVYLYIW NVVNGTIGKQ MVDTLVESST NVEMILKFFD MFLKLKDLTS
     SDTFKEYDPD GKGIISKKEF QKAMEGQKQY TQSEIDFLLS CAEADENDMF NYVDFVDRFH
     EPAKDIGFNV AVLLTNLSEH MPNDSRLKCL LDPAESVLNY FEPYLGRIEI MGGAKKIERV
     YFEISESSRT QWEKPQVKES KRQFIFDVVN EGGEQEKMEL FVNFCEDTIF EMQLASQISE
     SDSADRPEEE EEDEDSSYVL EIAGEEEEDG SLEPASAFAM ACASVKRNVA DFLKKATLKN
     LRKQYRNVKK MTAKELVKVF FSFFWMLFVG LFQLLFTILG GVFQILWSTV FGGGLVEGAK
     NIRVTKILGD MPDPTQFGIH DDTMEAERAE VMEPGITTEL VHFIKGEKGD TEIMSDLFGL
     HPKKEGSLKH GPEVGLGDLS EIIGKDEPPT LESTVQKKRK AQAAEMKAAN EAEGKESEKA
     DINYSNCYEK EDKDKEEEQA EYLWTEVTKK KKRRCGQKVE KPEAFTANFF KGLEIYQTKL
     LHYLARNFYN LRFLALFVAF AINFILLFYK VTEEPLEEET EDVANLWNSF NDEEEEEAMV
     FFVLQESTGY MAPTLRALAI IHTIISLVCV VGYYCLKVPL VVFKREKEIA RKLEFDGLYI
     TEQPSEDDIK GQWDRLVINT PSPCHPLFQV INKYGDLYGA ERIAELLGLD KNALDFSPVE
     ETKAEAASLV SWLSSIDMKY HIWKLGVVFT DNSFLYLAWY TTMSVLGHYN NFFFAAHLLD
     IAMGFKTLRT ILSSVTHNGK QLVLTVGLLA VVVYLYTVVA FNFFRKFYNK SEDDDEPDMK
     CDDMMTCYLF HMYVGVRAGG GIGDEIEDPA GDPYEMYRIV FDITFFFFVI VILLAIIQGL
     IIDAFGELRD QQEQVREDME TKCFICGIGN DYFDTTPHGF ETHTLQEHNL ANYFDGSCSI
     NKLLLWFKNK HPLCWDFFPA GDCFRKQYED QLG
//
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