ID A0A2I3G7N0_NOMLE Unreviewed; 250 AA.
AC A0A2I3G7N0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Protein-L-isoaspartate(D-aspartate) O-methyltransferase {ECO:0000256|ARBA:ARBA00040923};
DE EC=2.1.1.77 {ECO:0000256|ARBA:ARBA00011890};
DE AltName: Full=L-isoaspartyl protein carboxyl methyltransferase {ECO:0000256|ARBA:ARBA00031350};
DE AltName: Full=Protein L-isoaspartyl/D-aspartyl methyltransferase {ECO:0000256|ARBA:ARBA00042126};
DE AltName: Full=Protein-beta-aspartate methyltransferase {ECO:0000256|ARBA:ARBA00031323};
GN Name=PCMT1 {ECO:0000313|Ensembl:ENSNLEP00000027431.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000027431.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000027431.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000027431.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-L-isoaspartate + S-adenosyl-L-methionine =
CC [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:12705, Rhea:RHEA-COMP:12143, Rhea:RHEA-
CC COMP:12144, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90596,
CC ChEBI:CHEBI:90598; EC=2.1.1.77;
CC Evidence={ECO:0000256|ARBA:ARBA00035815};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12706;
CC Evidence={ECO:0000256|ARBA:ARBA00035815};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC isoaspartyl/D-aspartyl protein methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005369}.
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DR EMBL; ADFV01166511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01166512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01166513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01166514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01166515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01166516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01166517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01166518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01166519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004087710.1; XM_004087662.2.
DR AlphaFoldDB; A0A2I3G7N0; -.
DR Ensembl; ENSNLET00000055878.1; ENSNLEP00000027431.1; ENSNLEG00000029634.1.
DR GeneID; 100600871; -.
DR CTD; 5110; -.
DR GeneTree; ENSGT00950000183032; -.
DR OrthoDB; 303909at2759; -.
DR Proteomes; UP000001073; Chromosome 3.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR000682; PCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11579; PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11579:SF7; PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE; 1.
DR Pfam; PF01135; PCMT; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01279; PCMT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
SQ SEQUENCE 250 AA; 26627 MW; 61F2AC5C9B907733 CRC64;
MPGARSGGSG GDGSNSGSYS GDASGAVTVW EVVSLLGKLL GTVVALKVVL YLLRVCLAMA
WKSGGASHSE LIHNLRKNGI IKTDKVFEVM LATDRSHYAK CNPYMDSPQS IGFQATISAP
HMVGCTGKVI GIDHIKELVD DSINNVRKDD PTLLSSGRVQ LVVGDGRMGY AEEAPYDAIH
VGAAAPVVPQ ALIDQLKPGG RLILPVGPAG GNQMLEQYDK LQDGSVKMKP LMGVIYVPLT
DKEKQWSRWK
//
