ID A0A2I3G7N3_NOMLE Unreviewed; 732 AA.
AC A0A2I3G7N3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Host cell factor C2 {ECO:0000313|Ensembl:ENSNLEP00000027408.1};
GN Name=HCFC2 {ECO:0000313|Ensembl:ENSNLEP00000027408.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000027408.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000027408.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000027408.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; ADFV01052629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01052630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01052631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01052632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01052633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3G7N3; -.
DR STRING; 61853.ENSNLEP00000027408; -.
DR Ensembl; ENSNLET00000046256.1; ENSNLEP00000027408.1; ENSNLEG00000029553.1.
DR GeneTree; ENSGT00940000160733; -.
DR InParanoid; A0A2I3G7N3; -.
DR OMA; GWIPVPE; -.
DR Proteomes; UP000001073; Chromosome 10.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0071339; C:MLL1 complex; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IEA:Ensembl.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:Ensembl.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:1902615; P:immune response involved in response to exogenous dsRNA; IEA:Ensembl.
DR GO; GO:0034139; P:regulation of toll-like receptor 3 signaling pathway; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 6.10.250.2590; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR043536; HCF1/2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR PANTHER; PTHR46003; HOST CELL FACTOR; 1.
DR PANTHER; PTHR46003:SF2; HOST CELL FACTOR 2; 1.
DR Pfam; PF01344; Kelch_1; 1.
DR Pfam; PF13415; Kelch_3; 1.
DR Pfam; PF13854; Kelch_5; 1.
DR SMART; SM00060; FN3; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR PROSITE; PS50853; FN3; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 523..615
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 355..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 732 AA; 80074 MW; 606189134B8BCC3A CRC64;
WRRVSPSRGP VPRARHGHRA VAIRELMIIF GGGNEGIADE LHVYNTATNQ WFLPAVRGDI
PPGCAAHGFV CDGTRILVFG GMVEYGRYSN ELYELQASRW LWKKVKPHPP PSGLPPCPRL
GHSFSLYGNK CYLFGGLANE SEDSNNNVPR YLNDFYELEL QHGSGVVGWS IPVTKGVMPS
PRESHTAVIY CKKDSGSPKM YVFGGMCGAR LDDLWQLDLE TMSWSKPETK GTVPLPRSLH
TASVIGNKYG GFLYFASVFF LKNNLRSTQR NGRDGYKKAL NSQVCCKDLW YLDTEKPPAP
SQVQLIKATT NSFHVKWDEV STVEGYLLQL STDLPYQAAS PDSSAALNMQ GVRMDPHRQG
GNNIVPNSIS DTINSTKTEQ PATKETSMKN KPDFKALTDS NAILYPSLAS NASNHNSHVV
DMLRKNEGPH TSANVGVLSS CLDVRTVIPE TSVSSTVSST QTMVTQQTIK TESSSTNGAV
VKDETSLTTF STKSEVDETY ALPATKISRV ETHATATPFS KETPSNPVAT VKAGERQWCD
VGIFKNNTAL VSQFYLLPKG KQSISKVGNA DVPDYSLLKK QDLVPGTGYR FRVAAINGCG
IGPFSKISEF KTCIPGFPGA PSAVRISKNV EGIHLSWEPP TSPSGNILEY SAYLAIRTAQ
IQDNPSQLVF MRIYCGLKTS CIVTAGQLAN AHIDYTSRPA IVFRISAKNE KGYGPATQVR
WLQGNNKKAP LN
//
