ID A0A2I3G7S7_NOMLE Unreviewed; 2253 AA.
AC A0A2I3G7S7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Filamin A {ECO:0000313|Ensembl:ENSNLEP00000027456.1};
GN Name=FLNA {ECO:0000313|Ensembl:ENSNLEP00000027456.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000027456.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000027456.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000027456.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR EMBL; ADFV01117816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01117817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01117818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01117819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01117820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01117821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000038052.1; ENSNLEP00000027456.1; ENSNLEG00000013842.2.
DR GeneTree; ENSGT00940000153588; -.
DR Proteomes; UP000001073; Chromosome X.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21308; CH_FLNA_rpt1; 1.
DR CDD; cd21312; CH_FLNA_rpt2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 19.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537:SF5; FILAMIN-A; 1.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 19.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 19.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 19.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 19.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 16..122
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 139..242
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 249..347
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 349..447
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 448..543
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 544..636
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 640..736
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 737..839
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 840..939
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1008..1093
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1094..1188
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1189..1289
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1357..1453
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1454..1550
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1563..1654
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1682..1774
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1774..1866
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1862..1931
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1933..2026
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2030..2122
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2158..2252
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 244..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2253 AA; 239777 MW; DE03B9173AF646C6 CRC64;
MPATEKDLAE DAPWKKIQQN TFTRWCNEHL KCVSKRIANL QTDLSDGLRL IALLEVLSQK
KMHRKHNQRP TFRQMQLENV SVALEFLDRE SIKLVSIDSK AIVDGNLKLI LGLIWTLILH
YSISMPMWDE EEDEEAKKQT PKQRLLGWIQ NKLPQLPITN FSRDWQSGRA LGALVDSCAP
GLCPDWDSWD ASKPVTNARE AMQQADDWLG IPQVITPEEI VDPNVDEHSV MTYLSQFPKA
KLKPGAPLRP KLNPKKARAY GPGIEPTGNM VKKRAEFTVE TRSAGQGEVL VYVEDPAGHQ
EEAKVTANND KNRTFSVWYV PEVTGTHKVT VLFAGQHIAK SPFEVYVDKS QGDASKVTAQ
GPGLEPSGNI ANKTTYFEIF TAGAGTGEVE VVIQDPVGRK GTVEPQLEAR GDSTYRCSYQ
PTMEGVHTVH VTFAGVPIPR SPYTVTVGQA CNPSACRAVG RGLQPKGVRV KETADFKVYT
KGAGSGELKV TVKGPKGEER VKQKDLGDGV YGFEYYPMVP GTYIVTITWG GQNIGRSPFE
VKVGTECGNQ KVRAWGPGLE GGVVGKSADF VVEAIGDDVG TLGFSVEGPS QAKIECDDKG
DGSCDVRYWP QEAGEYAVHV LCNSEDIRLS PFMADIRDAP QDFHPDRVKA RGPGLEKTGV
AVNKPAEFTV DAKHGGKAPL RVQVQDNEGC PVEALVKDNG NGTYSCSYVP RKPVKHTAMV
SWGGVSIPNS PFRVNVGAGS HPNKVKVYGP GVAKTGLKAH EPTYFTVDCT EAGQGDVSIG
IKCAPGVVGP AEADIDFDII RNDNDTFTVK YTPRGAGSYT IMVLFADQAT PTSPIRVKVE
PSHDASKVKA EGPGLSRTGV ELGKPTHFTV NAKAAGKGKL DVQFSGLTKG DAVRDVDIID
HHDNTYTVKY TPVQQEGPYE VEVTYDGVPV PGSPFPLEAV APTKPSKVIG VWEALRVEPT
VLSEGPKASQ VAGITGAPRA RGGRWRVRQE VWDQGHSVAL APDPFFLQVK AFGPGLQGGS
AGSPARFTID TKGAGTGGLG LTVEGPCEAQ LECLDNGDGT CSVSYVPTEP GDYNINILFA
DTHIPGSPFK AHVVPCFDAS KVKCSGPGLE RATAGEVGQF QVDCSSAGSA ELTIEICSEA
GLPAEVYIQD HGDGTHTITY IPLCPGAYTV TIKYGGQPVP NFPSKLQVEP AVDTSGVQCY
GPGIEGQGVF REATTEFSVD ARALTQTGGP HVKARVANPS GNLTETYVQD RGNGTYQVEY
TPYEEGATAL CGCDYDGSPV PSSPSRAATP PGCVSHGPGI QSGTTNKPNK FTPVWLVGLG
TPGTTGSARS STSLTRLAPT GWDCLLVPTL PFKVPVHDVT DASKVKCSGP GLSPGMVRAN
LPQSFQVDTS KAGVAPLQVK VQGPKGLVEP VDVVDNADGT QTVNYVPSRE GPYSISVLYG
DEEVPRSPFK VKVLPTHDAS KVKASGPGLN TTGVPASLPV EFTIDAKDAG EGLLAVQITD
PEGKPKKTHI QDNHDGTYTV AYVPDVTGRY TILIKYGGDE IPFSPYRVRA VPTGDASKCT
VTVSIGGHGL GAGIGPTIQI GEETVITVDT KAAGKGKVTC TVCTPDGSEV DVDVVENEDG
TFDIFYTAPQ PGKYVICVRF GGEHVPNSPF QVTALAGDQP SVQPPLRSQQ LAPQYTYAQG
GQQTWAPERP LVGVNGLDMT SLRPFDLVIP FTIKKGEITG EVRMPSGKVA QPAITDNKDG
TVTVRYAPSE AGLHEMDIRY DNMHIPGSPL QFYVDYVNCG HVTAYGPGLT HGVVNKPATF
TVNTKDAGEG GLSLAIEGPS KAEISCTDNQ DGTCSVSYLP VLPGDYSILV KYNEQHIPGS
PFTARVTGDD SMRMSHLKVG SAGPSKAEIS FEDRKDGSCG VAYVVQEPGD YEVSVKFNEE
HIPDSPFVVP VASPSGDARR LTVSSLQESG LKVNQPASFA VSLNGAKGAI DAKVHSPSGA
LEECYVTEID QDKYAVRFIP RENGVYLIDV KFNGTHIPGS PFKIRVGEPG HGGDPGLVSA
YGAGLEGGVT GNPAEFIVNT SNAGAGALSV TIDGPSKVKM DCQECPEGYR VTYTPMAPGS
YLISIKYGGP YHIGGSPFKA KVTGPRLVSN HSLHETSSVF VDSLTKATCA PQHGAPGPGP
ADASKVVAKG LGLSKAYIGQ KSSFTVDCSK AGNNMLLVGV HGPRTPCEEI LVKHVGSRLY
SVSYLLKDKG EYTLVVKWGD EHIPGSPYRV VVP
//
