ID   A0A2I3G8P1_NOMLE        Unreviewed;       860 AA.
AC   A0A2I3G8P1;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=MCF.2 cell line derived transforming sequence {ECO:0000313|Ensembl:ENSNLEP00000027729.1};
GN   Name=MCF2 {ECO:0000313|Ensembl:ENSNLEP00000027729.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000027729.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000027729.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000027729.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ADFV01072319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01072320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01072321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01072322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003272640.1; XM_003272592.2.
DR   AlphaFoldDB; A0A2I3G8P1; -.
DR   Ensembl; ENSNLET00000040970.1; ENSNLEP00000027729.1; ENSNLEG00000003068.3.
DR   GeneTree; ENSGT00940000156974; -.
DR   Proteomes; UP000001073; Chromosome X.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd00176; SPEC; 1.
DR   Gene3D; 1.20.58.60; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00150; SPEC; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT   DOMAIN          13..88
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   DOMAIN          495..675
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          687..809
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   COILED          244..274
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   860 AA;  100269 MW;  934FE605F55ABA52 CRC64;
     MAEANPPRGK MRFRRNAASF PGNLHLVLVL RPTSFLQRTF TDIGFRFSQE DFMLKLPVVM
     LSSVSDLLTY IDDKQLTPEL GGTLQYCHSE WIIFRNAIEN FALTVKEMAQ MLQSFGTELA
     ETELPDDIPS IEEILAIRAE RYHLLKNDIT AVTKEGKILL TNLEVPDTEG AVSSRLECHQ
     QISGDWQTIN KLLTQVHDME TAFDGFWEKH QLKMEQYLQL WKFEQDFQQL VTEVEFLLNQ
     QAELADVTGT IAQVKQKIKK LENLDENSQE LLSKAQFVIL HGHKLAANHH YALDLICQRC
     NELRYLSDIL VNEIKAKQKQ LSRTFKMHKL LQQARQCCDE GECLLANQEI DKFQSKEDAQ
     KALQDIENFL EMALPFINYE PETLQYEFDV ILSPELKVQM KTIQLKLENI RSIFENQQAG
     FRNLADKHVR PIQFVVPTPE NLVTSGTPFF SSKQGKKTWR QNQSNLKIEV LHDCQEKRSS
     GESSSLDNGN SLDVLKNHVL NELIQTERVY VQELYTVLLG YRAEMDNPEM FDLMPSLLRN
     KKDVLFGNMA EIYEFHNDIF LSNLENCAYA PERVGPCFLE RKDDFQMYAK YCQNKPRSET
     IWRKYSECAF FQECQRKLNH KLRLDSYLLK PVQRITKYQL LLKELLKYSK DCEGSALLKE
     ALDAMLDLLK SVNDSMHQIA INGYIGNLNE LGKMIMQGGF SVWIGHKKGA TKMKDLARFK
     PMQRHLFLYE KAIVFCKRRV ESGEGSDRYP SYNFKHCWKM DEVGITEYVK GDNRKFEIWY
     GEKEEVYIVQ ASNVDVKMTW LKEIRNILLK QQELLTVKKR KQQDQLTERD KIQISLQQND
     EDPCRRWLSY IDEATVSNGK
//