ID A0A2I3G936_NOMLE Unreviewed; 1284 AA.
AC A0A2I3G936;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=FERM and PDZ domain containing 2 {ECO:0000313|Ensembl:ENSNLEP00000027815.1};
GN Name=FRMPD2 {ECO:0000313|Ensembl:ENSNLEP00000027815.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000027815.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000027815.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000027815.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01105677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01105678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01105679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01105680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01105681; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01105682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01105683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000037803.1; ENSNLEP00000027815.1; ENSNLEG00000015507.2.
DR GeneTree; ENSGT00940000161964; -.
DR Proteomes; UP000001073; Chromosome 18.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13187; FERM_C_PTPH13; 1.
DR CDD; cd17196; FERM_F1_FRMPD2; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011019; KIND_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46900:SF3; FERM AND PDZ DOMAIN-CONTAINING 2; 1.
DR PANTHER; PTHR46900; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00595; PDZ; 3.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00750; KIND; 1.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51377; KIND; 1.
DR PROSITE; PS50106; PDZ; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1284
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014197746"
FT DOMAIN 13..173
FT /note="KIND"
FT /evidence="ECO:0000259|PROSITE:PS51377"
FT DOMAIN 318..617
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 750..836
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 925..1010
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1054..1142
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 191..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1175..1231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1284 AA; 141524 MW; 3E273706AED161D8 CRC64;
MHVFIVGMSL SSVTLASALQ VRGEALSEEE IWSLLFLAAE QLLEDLRNDS LDYVVCPWSA
LLSAAGSLSF QGHVSHIEAA PFKAPELLQG QSEDEQPDAS QPLQLREPLH SILLTMCEDQ
PHRRCTLQSV LEACRVHEKE VSVYPAPAGL HIRRLVGLVL GTISEVEKRV VEETSSVQQN
RSYLLRKRLH GTSSESPAAQ APECLHPCRV SERSTETQSS PEPRWSTSTH SHCSLLVNRT
LPGADPQDQQ EGRRLSSGSV HSAADSSWPT TPSQRGFLQR RSKFSRPEFI LLAGEAPMTL
HLPGSVVTKK GKSYLALRDL CVVLLNGQHL EVKCDVESTV GAVFNAVTSF ANLEEFTYFG
LAYMKGKEFF FLDSETRLCK IAPEGWREQP QKTSMNTFTL FLRIKFFVSH YGLLQHSLTR
HQFYLQLRKD ILEERLYCNE EMLLQLGVLA LQAEFGNYPK EVESKPYFHV EDYIPVSLIE
RMTALRVQVE VSEMHRLGSA LWGEDAELEF LKVTQQLPEY GVLVHQVFSE KRRPEEEMAL
GICAKGVIVY EVKNNSRIAT LRFQWRETGK ISTYQKKFTI TSSVTGKKHT FVTDSAKTSK
YLLDLCSAQH GFNAQMGSGQ PSHVLFDHDK FVQMANLSPA HQAQSKPLIW IQRLSCSENE
LFASRLQDAG GGLLSTSLDN FNVDGSKEAG AEGIGRSPCT GREQLKSACV IQKPMTWDSL
SGPPVQSMHA GSKNNRRKSF TAEPGREIVC VTLKRDPHRG FGFVINEGEY SGQADPGIFI
SSVIPGGPAE KAKTIKPGGQ ILALNHISLE GFTFNMAVRM IQNSPDNIEL IISQSKGVGG
NNPDEEKNST ANSGVSSTDI LSFGYQGSLL SHTQDQDRNI EELDMAGVQS LVPRLRHQLS
FLPLKGAASS CPPSPPEISA GEIYFVELVK EDGTLGFSVT GGINTSVPYG GIYVKSIVPG
GPAAKEGQIL QGDRLLQVDG VSLCGLTHKQ AVHCLKGPGQ VARLVLERRG PRTTQQCPSA
NDSMGDEHTA VSLVTALPGR PSSCVSVTDG PKFEVKLKKN VNGLGFSFVQ MEKESCSQLK
SDLVRIKRLF PGQPAEENGA IAAGDIILAV NGRSTEGLIF QEVLHLLRGA PQEVTLLLCR
PPPGALPEME QEWQTPELSA DKEFTRATRT DSCTSPILDQ EDNWRDSASP DAGEGLGLRP
ESSQKAIREA QWGQNRERPW ASSLTHSPES HPHLCKLHQE RDASTLATSL EKDMRQNCYS
VCDIMRLGRY SFSSPLTRLS TDIF
//
