ID A0A2I3GA84_NOMLE Unreviewed; 501 AA.
AC A0A2I3GA84;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Rap guanine nucleotide exchange factor 3 {ECO:0000313|Ensembl:ENSNLEP00000028197.1};
GN Name=RAPGEF3 {ECO:0000313|Ensembl:ENSNLEP00000028197.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000028197.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000028197.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000028197.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01003358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01003359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01003360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01003361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01003362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01003363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01003364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01003365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GA84; -.
DR Ensembl; ENSNLET00000046086.1; ENSNLEP00000028197.1; ENSNLEG00000017905.3.
DR GeneTree; ENSGT00940000159931; -.
DR Proteomes; UP000001073; Chromosome 8.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR043533; CNBD1/2.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR23011:SF32; CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23011; UNCHARACTERIZED; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00135};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 148..249
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 287..421
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
SQ SEQUENCE 501 AA; 55363 MW; BCB477660D710F6F CRC64;
MKVGWPGESC WQVGLAVEES PALGAPRVGA PPDVVPEGTL LNMVLRRMHR PRSCSYQLLL
EHQRPSCIQG LRWTPLTNSE ESLDFSESLE QASTERVLRA GRQLHRHLLA TCPNLIRDRK
YHLRLYRPGQ RTDEELDLIF EELLHIKAVA HLSNSVKREL AAVLQFEPHS KAGTVLFSQG
DKGTSWYIIW KGSVNVVTHG KGLVTTLHEG DDFGQLALVN DAPRAATIIL REDNCHFLRV
DKQDFNRIIK DVEAKTMRLE EHGKVVLVLE RASQGAGPSG PPTPGRNRYT VMSGTPEKIL
ELLLEAMGPD SSAHDPTETF LSDFLLTHRV FMPSAQLCAA LLHHFHAEPA GGSEQERSTY
VCNKRQQILR LVSQWAALYG SMLHTDPVAT SFLQKLLDLV GRDTRLSNLL REQWPERRRY
HRLENGCGNA SPQMKVSAWP QLLSSAPPGL QAPPSPPDPE GLCVRGKLSS HRHTLGSVIG
VHGALAACGA LGQAMPGGAE A
//
