ID A0A2I3GBC0_NOMLE Unreviewed; 295 AA.
AC A0A2I3GBC0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Growth hormone receptor {ECO:0000313|Ensembl:ENSNLEP00000028619.1};
GN Name=GHR {ECO:0000313|Ensembl:ENSNLEP00000028619.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000028619.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000028619.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000028619.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 1
CC subfamily. {ECO:0000256|ARBA:ARBA00007885}.
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DR EMBL; ADFV01081327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01081328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01081329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01081330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01081331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01081332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01081333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01081334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01081335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GBC0; -.
DR Ensembl; ENSNLET00000038163.1; ENSNLEP00000028619.1; ENSNLEG00000016678.3.
DR GeneTree; ENSGT00940000159987; -.
DR Proteomes; UP000001073; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR GO; GO:0060396; P:growth hormone receptor signaling pathway; IEA:UniProt.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR015152; Growth/epo_recpt_lig-bind.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003528; Long_hematopoietin_rcpt_CS.
DR PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23037:SF41; CYTOKINE RECEPTOR-LIKE FACTOR 2-RELATED; 1.
DR Pfam; PF09067; EpoR_lig-bind; 1.
DR Pfam; PF00041; fn3; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01352; HEMATOPO_REC_L_F1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..295
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014162986"
FT TRANSMEM 264..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 151..254
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 295 AA; 33898 MW; 652F36455D31FB8F CRC64;
MDLWQLLLTL ALAGSSDAFS GSEATAAILS RESWSLQSVN PGLKTNSSKE PKFTKCRSPE
RETFSCHWTD AVLHGSKSLG PIQLFYTRRN TQEWTQEWKE CPDYVSAGEN SCYFNSSFTS
IWIPYCIKLT SNGGTMDEKC FSVDEIVQPD PPIALNWTLL NVSLTGIHAD IQVRWEAPPN
ADIQKGWMVL EYELQYKEVN ETKWKMMDPI LSTSVPVYSL KVDKEYEVRV RSKQRNSGNY
GEFSEVLYVT LPPMSQFTCE EDFYFPWLLI IIFGIFGLTV MLFVFLFSKQ QRKEN
//
