ID A0A2I3GC65_NOMLE Unreviewed; 1902 AA.
AC A0A2I3GC65;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=LDL receptor related protein 4 {ECO:0000313|Ensembl:ENSNLEP00000028873.1};
GN Name=LRP4 {ECO:0000313|Ensembl:ENSNLEP00000028873.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000028873.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000028873.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000028873.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; ADFV01115812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000052626.1; ENSNLEP00000028873.1; ENSNLEG00000014206.3.
DR GeneTree; ENSGT00940000158287; -.
DR Proteomes; UP000001073; Chromosome 15.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00058; Ldl_recept_b; 16.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 16.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1902
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014182592"
FT TRANSMEM 1721..1744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 415..430
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 477..519
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 520..562
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 563..606
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 607..649
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 782..824
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 825..867
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 868..911
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 912..954
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1090..1132
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1133..1175
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1176..1219
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1220..1261
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1394..1436
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1437..1479
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1480..1523
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1524..1565
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 1658..1686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1849..1902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1664..1683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1849..1878
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1885..1902
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 48..63
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 68..80
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 75..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 87..102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 107..119
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 114..132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 145..157
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 152..170
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 164..179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 188..200
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 195..213
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 207..222
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 228..240
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 235..253
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 247..262
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 267..279
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 274..292
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 286..301
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 309..321
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 316..334
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1902 AA; 211747 MW; 5B84D6DB641D5DBF CRC64;
EKKKDGCIIM KLLLCLASSP ECACGRSHFT CAVSALGECT CIPAQWQCDG DNDCGDHSDE
DGCMLPTCSP LDFHCDNGKC IRRSWVCDGD NDCEDDSDEQ DCPPRECEED EFPCQNGYCI
RSLWHCDGDN DCGDNSDEQC DMRKCSDKEF RCSDGSCIAE HWYCDGDTDC KDGSDEESCP
SAVPAPPCNL EEFQCAYGHC ILDIYHCDGD DDCGDWSDES DCASHQPCRS GEFMCDSGLC
INAGWRCDGD ADCDDQSDER NCTTSMCTAE QFRCRSGRCV RLSWRCDGED DCADNSDEEN
CENTGSPQCA SDQFLCWNGR CIGQRKLCNG VNDCGDNSDE SPQQNCRPRT GEENCNVNNG
GCAQKCQMVR GVVQCTCHTG YRLTEDGHTC QDVNECAEEG YCSQGCTNSE GAFQCWCETG
YELRPDRRSC KALGPEPVLL FANRIDIRQV LPHRSEYTLL LNNLENAIAL DFHHRRELVF
WSDVTLDRIL RANLNGSNVE EVVSTGLESP GGLAVDWVHD KLYWTDSGTS RIEVANLDGA
HRKVLLWQNL EKPRAIALHP MEGTIYWTDW GNTPRIEASS MDGSGRRIIA DTHLFWPNGL
TIDYAGRRMY WVDAKHHVIE RANLDGSHRK AVISQGLPHP FAITVFEDSL YWTDWHTKSI
NSANKFTGKN QEIIRNKLHF PMDIHTLHPQ RQPAGKNRCG DNNGGCTHLC LPSGQNYTCA
CPTGFRKISS HACAQSLDKF LLFARRMDIR RISFDTEDLS DDVIPLADVR SAVALDWDSR
DDHVYWTDVS TDTISRAKWD GTGQEVVVDT SLESPAGLAI DWVTNKLYWT DAGTDRIEVA
NTDGSMRTVL IWENLDRPRD IVVEPMGGYM YWTDWGASPK IERAGMDASG RQVIISSNLT
WPNGLAIDYG SQRLYWADAG MKTIEFAGLD GSKRKVLIGS QLPHPFGLTL YGERIYWTDW
QTKSIQSADR LTGLDRETLQ ENLENLMDIH VFHRRRPPVS TPCAVENGGC SHLCLRSPNP
SGFSCTCPTG INLLSDGKTC SPGMNSFLIF ARRIDIRMVS LDIPYFADVV VPINITMKNT
IAIGVDPQEG KVYWSDSTLH RISRANLDGS QHEDIITTGL QTTDGLAVDA IGRKVYWTDT
GTNRIEVGNL DGSMRKVLVW QNLDSPRAIV LYHEMGFMYW TDWGENAKLE RSGMDGSDRA
VLINNNLGWP NGLTVDKTSS QLLWADAHTE RIEAADLNGA NRHTLVSPVQ HPYGLTLLDS
YIYWTDWQTR SIHRADKGTG SNVILVRSNL PGLMDIQAVD RAQPLGFNKC GPRNGGCSHL
CLPRPSGFSC ACPTGIQLKG DGKTCDPSPE TYLLFSSRGS IRRISLDTSD HTDVHVPVPE
LNNVISLDFD SVDGKVYYTD VFLDVIRRAD LNGSNMETVI GRGLKTTDGL AVDWVARNLY
WTDTGRNTIE ASRLDGSCRK VLINNSLDEP RAIAVFPRKG YLFWTDWGHI AKIERANLDG
SERKVLINTD LGWPNGLTLD YDTRRIYWVD AHLDRIESAD LNGKLRQVLV SHVSHPFALT
QQDRWIYWTD WQTKSIQRVD KYSGRNKETV LANVEGLMDI IAVSPQRQTG TNACGVNNGG
CTHLCFARAS DFVCACPDEP DSRPCSFVPG LVPPAPRATG MSEKSPVLPN TPPTTLHSST
TRTRTSLEEV EGRCSERDAR LGLCARSNEA VPAAPGEGLH ISYAIGGLLS ILLILVVTAA
LMLYRHKKSK FTDPGMGNLT YSNPSYRTST QEVKIEAIPK PAMYNQLCYK KEGGPDHNYT
KEKIKIVEGI CLLSGDDAEW DDLKQLRSSR GGLLRDHVCM KTDTVSIQAS SGSLDDTETE
QLLQEEQSEC SSVHTAATPE RRGSLPDTGW KHERKLSSES QV
//
