ID A0A2I3GCH3_NOMLE Unreviewed; 995 AA.
AC A0A2I3GCH3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Adhesion G protein-coupled receptor G2 {ECO:0000313|Ensembl:ENSNLEP00000028985.1};
GN Name=ADGRG2 {ECO:0000313|Ensembl:ENSNLEP00000028985.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000028985.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000028985.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000028985.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; ADFV01194634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01194635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01194636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01194637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003261170.1; XM_003261122.1.
DR AlphaFoldDB; A0A2I3GCH3; -.
DR Ensembl; ENSNLET00000059139.1; ENSNLEP00000028985.1; ENSNLEG00000009745.3.
DR GeneID; 100585341; -.
DR CTD; 10149; -.
DR GeneTree; ENSGT00940000156341; -.
DR OrthoDB; 4370914at2759; -.
DR Proteomes; UP000001073; Chromosome X.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15444; 7tmB2_GPR64; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF264; ADHESION G-PROTEIN COUPLED RECEPTOR G2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023040};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 608..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 678..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 713..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 762..791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..832
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 838..860
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 606..861
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 302..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 896..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 995 AA; 109052 MW; 352421DE98C15779 CRC64;
MVFSGRQCGH VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP PAKLSVVSFA
PSSNGTPDVT LSLLPSNETG VKPQRNICNL SSICNDSAFF RGEIMFQYDK ESTVPQNQHI
TNGTLTGVLS LSELKRSELN KTLQTLSETY FIMCATAEAQ STLNCTFTIK LNNTMNACAV
IAALERVKIQ PMEHCCCSVR TPCPSSPEEL EKLQCDLQDP IVCLADHPRG PPFSSSQSIP
VVPRATVLSQ VPNATSFAEP PDYSPMTHNV PSLIGEIHPL SPQPSAPIAS SPAIDMPPQS
ETISSPMPQT HVSGTPPPVK ASFSSPTVSA PANVITTSAP PVQTDIVNTS SISDLENQVS
QMEKALSLGS LEPNLAGEMI NQVSRLLHSP PDMLAPLAQR LLKVVDDIGL QLNFSNTTIS
LTSPSLALAV IRVNASSFNT TTFVAQDPAN LQVSLETQAP ENSIGTITLP SSLMNNLPAN
DMELASRVQF NFFETPALFQ DPSLENLSLI SYVISSSVAN LTVRNLTRNV TVTLKHINLS
QDELTVRCVF WDLGRNGGRG GWSDDGCSVK DRRLNETICT CSHLTSFGVL LDLSRTSVLP
AQTMALTFIT YIGCGLSSIF LSVTLVTYIA FEKIRRDYPS KILIQLCAAL LLLNLVFLLD
SWIALYKMQG LCISVAVFLH YFLLVSFTWM GLEAFHMYLA LVKVFNTYIR KYILKFCIVG
WGVPAVVVAI ILTISPDNYG LGSYGKFPNG SPDDFCWINN NAVFYITVVG YFCVIFLLNV
SMFIVVLVQL CRIKKKKQLG AQRKTSIQDL RSIAGLTFLL GITWGFAFFA WGPVNVTFMY
LFAIFNTLQG FFIFIFYCVA KENVRKQWRR YLCCGKLRLA ENSDWSKTAT NGLKKQTVNQ
GVSSSSNSLQ SNSNSTNSTT LLVNNDCSVH ASGNGNASTE RNGVSFSVQN GDVCLHDFTG
KQHMFNEKED SCNGKGRMAL RRTSKRGSLH FIEQM
//
