ID A0A2I3GD52_NOMLE Unreviewed; 767 AA.
AC A0A2I3GD52;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=LDL receptor related protein 3 {ECO:0000313|Ensembl:ENSNLEP00000029236.1};
GN Name=LRP3 {ECO:0000313|Ensembl:ENSNLEP00000029236.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000029236.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000029236.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000029236.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, coated pit
CC {ECO:0000256|ARBA:ARBA00037878}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; ADFV01085784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01085785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01085786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GD52; -.
DR Ensembl; ENSNLET00000051299.1; ENSNLEP00000029236.1; ENSNLEG00000007676.2.
DR GeneTree; ENSGT00940000160021; -.
DR Proteomes; UP000001073; Chromosome 10.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 4.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF22; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 5.
DR SUPFAM; SSF57424; LDL receptor-like module; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 4.
PE 4: Predicted;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 494..520
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..156
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 251..362
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 632..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..686
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..703
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 163..175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 170..188
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 182..197
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 231..246
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 434..449
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 452..464
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 459..477
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 471..486
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 767 AA; 82482 MW; F5236E56542EC199 CRC64;
MEKRAAAGLE GAPGARAQLA VVCLGEWAGL SRPPLLTAAC SGKLEQHTER RGVIYSPAWP
LNYPPGTNCS WYIQGDRGDM ITISFRNFDV EESHQCSLDW LLLGPAAPPR QEAFRLCGSA
IPPAFISARD HVWIFFHSDA SSSGQAQGFR LSYIRGKLGQ ASCQADEFRC DNGKCLPGPW
QCNTVDECGD GSDEGNCSAP ASEPPGSLCP GGTFPCSGAR STRCLPVERR CDGLQDCGDG
SDEAGCPDLA CGRRLGSFYG SFASPDLFGA ARGPSDLHCT WLVDTQDSRR VLLQLELRLG
YDDYVQVYEG LGERGDRLLQ TLSYRSNHRP VSLEAAQGRL TVAYHARARS AGHGFNATYQ
VKGYCLPWEQ PCGSSSDSDG GSPGDQGCFS EPQRCDGWWH CASGRDEQGC PACPPDQYPC
EGGSGLCYTP ADRCNNQKSC PDGADEKNCF SCQPGTFHCG TNLCIFETWR CDGQEDCQDG
SDEHGCLAAV PRKVITAALI GSLVCGLLLV IALGCAFKLY SLRTQEYRAF ETQMTRLEAE
FVRREAPPSY GQLIAQGLIP PVEDFPVYSA SQASVLQNLR TAMRRQMRRH ASRRGPSRRR
LGRLWNRLFH RPRAPRGQIP LLTAARPSQT VLGDGFLQPA PGAAPDPPAP LMDTGSTRVA
GDGPPSAPGR APEVGPSGPP LPSGLRDPEC RPVDKDRKVC REPLADSPAP ADAPREPCSA
QDPHPQASTA SSTLGPHSPE PLGVCRSPPP PCSPMLEASD DEALLVC
//
