ID A0A2I3GEE4_NOMLE Unreviewed; 811 AA.
AC A0A2I3GEE4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=TLR4 interactor with leucine rich repeats {ECO:0000313|Ensembl:ENSNLEP00000029690.1};
GN Name=TRIL {ECO:0000313|Ensembl:ENSNLEP00000029690.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000029690.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000029690.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000029690.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01060530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003270515.1; XM_003270467.2.
DR AlphaFoldDB; A0A2I3GEE4; -.
DR STRING; 61853.ENSNLEP00000029690; -.
DR Ensembl; ENSNLET00000033426.1; ENSNLEP00000029690.1; ENSNLEG00000031765.1.
DR GeneID; 100595754; -.
DR KEGG; nle:100595754; -.
DR CTD; 9865; -.
DR GeneTree; ENSGT00940000161975; -.
DR InParanoid; A0A2I3GEE4; -.
DR OMA; PHDVLTY; -.
DR OrthoDB; 4599366at2759; -.
DR Proteomes; UP000001073; Chromosome 17.
DR GO; GO:0046696; C:lipopolysaccharide receptor complex; IEA:Ensembl.
DR GO; GO:0001530; F:lipopolysaccharide binding; IEA:Ensembl.
DR GO; GO:0002718; P:regulation of cytokine production involved in immune response; IEA:Ensembl.
DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR PANTHER; PTHR24373:SF307; TLR4 INTERACTOR WITH LEUCINE RICH REPEATS; 1.
DR Pfam; PF13855; LRR_8; 4.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..811
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014174044"
FT TRANSMEM 697..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 359..415
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 411..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 811 AA; 88739 MW; 8A3E969ABE6935FE CRC64;
MEAARAVRLL LVVCGCLALP PLAEPVCPER CDCQHPQHLL CTNRGLRVVP KTSSLPSPHD
VLTYSLGGNF ITNITAFDFH RLGQLRRLDL QYNQIRSLHP KTFEKLSRLE ELYLGNNLLQ
GLAPGTLAPL RKLRILYANG NDIGRLSRGS FEGLESLVKL RLDGNALGAL PDAVFAPLSN
LLYLHLESNR IRFLGKNAFA QLGKLRFLNL SANELQPSLR HAATFAPLRS LSSLILSANS
LQHLGPRVFQ HLPRLGLLSL RGNQLTHLAP EAFWGLEALR ELRLEGNRLS QLPTALLEPL
HSLEALDLSG NELSALHPAT FGHLGRLREL SLRNNALSAL SGDIFAASPA LYRLDLDGNG
WTCDCRLRGL KRWMGDWHSQ GRLLTVFVQC RHPPALRGKY LDYLDDQQLQ NGSCADPSPS
ASLTADRRRR PLPTASGEEM TPPAGLAEEL PPQPQLQQQG RFLAGVAWDG AARELVGNRS
ALRLSRRGPG LQQPSPSVAA AAGPAPQSLD LHEKPQRGRP TRADSAHAEP TPTASPGSAP
SPAGDSWQRA TKHRLGTEHQ ERAAQSDGGA GLPPLVSDPC DFNKFILCNL TVEAVGADSA
SVRWAVREHR SPRPLGGARF RLLFDRFGQQ PKFHRFVYLP ERSDSATLRE LRGDTPYLVC
VEGVLGGRVC PVAPRDHCAG LVTLPEAGSR GGVDYQLLTL ALLTVNALLV LLALAAWASR
WLRRKLRARR KGGAPVHVRH MYSTRRPLRS MGTGVSADFS GFQSHRPRTT VCALSEADLI
EFPCDRFMDS AGGGAGGSLR REDHLLQRFA D
//
