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Database: UniProt
Entry: A0A2I3GER4_NOMLE
LinkDB: A0A2I3GER4_NOMLE
Original site: A0A2I3GER4_NOMLE 
ID   A0A2I3GER4_NOMLE        Unreviewed;       819 AA.
AC   A0A2I3GER4;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-JUN-2019, entry version 14.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000029816};
GN   Name=ADAM9 {ECO:0000313|Ensembl:ENSNLEP00000029816};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000029816, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000029816, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000029816}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; ADFV01051379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01051380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01051381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01051382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003269645.1; XM_003269597.3.
DR   Ensembl; ENSNLET00000036345; ENSNLEP00000029816; ENSNLEG00000012378.
DR   GeneID; 100604235; -.
DR   KEGG; nle:100604235; -.
DR   CTD; 8754; -.
DR   GeneTree; ENSGT00940000156239; -.
DR   KO; K06834; -.
DR   OMA; GSPKECE; -.
DR   OrthoDB; 162519at2759; -.
DR   Proteomes; UP000001073; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005518; F:collagen binding; IEA:Ensembl.
DR   GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR   GO; GO:0043236; F:laminin binding; IEA:Ensembl.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:Ensembl.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
DR   GO; GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
DR   GO; GO:0033631; P:cell-cell adhesion mediated by integrin; IEA:Ensembl.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR   GO; GO:0006509; P:membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0042117; P:monocyte activation; IEA:Ensembl.
DR   GO; GO:0033630; P:positive regulation of cell adhesion mediated by integrin; IEA:Ensembl.
DR   GO; GO:0051549; P:positive regulation of keratinocyte migration; IEA:Ensembl.
DR   GO; GO:0034241; P:positive regulation of macrophage fusion; IEA:Ensembl.
DR   GO; GO:0050714; P:positive regulation of protein secretion; IEA:Ensembl.
DR   GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR   GO; GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
DR   GO; GO:0010042; P:response to manganese ion; IEA:Ensembl.
DR   GO; GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl.
DR   GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00117091};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAAS:SAAS01078504, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01078486,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01078482,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29    819       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014118618.
FT   TRANSMEM    699    718       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      212    406       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN      414    501       Disintegrin. {ECO:0000259|PROSITE:
FT                                PS50214}.
FT   DOMAIN      640    674       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   REGION      734    767       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2I3GER4}.
FT   REGION      780    819       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2I3GER4}.
FT   COMPBIAS    738    754       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2I3GER4}.
FT   DISULFID    473    493       {ECO:0000256|PROSITE-ProRule:PRU00068}.
FT   DISULFID    664    673       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   819 AA;  90303 MW;  2973ED598026A0AB CRC64;
     MGSGAGLPSG TLRVRWLLLL GLVGPVLGAA RPGFQQTSHL SSYEIITPWR LTRERREAPR
     PNSKQVSYVI QAEGKEHIIH LERNKDLLPE DFVVYTYNKE GTLITDHPNI QNHCHYRGYV
     EGVHNSSVGL SDCFGLRGLL HLENASYGIE PLQNSSHFEH IIYRMDDVHK EPLKCGVSSK
     DIEKETAKDE EEEPPSMTQL LRRRRAILPQ TRYVELFIVV DKERYDMMGR NQTAVREEMI
     LLANYLDSMY IMLNIRIVLV GLEIWTNGNL INIVGGAGDV LGNFVQWREK FLITRRRHDS
     AQLVLKKGFG GTAGMAFVGT VCSRSHAGGI NVFGQITVET FASIVAHELG HNLGMNHDDG
     RDCSCGAKSC IMNSGASGSR NFSSCSAEDF EKLTLNKGGN CLLNIPKPDE AYSAPSCGNK
     LVDAGEECDC GTPKECELDP CCEGSTCKLK SFAECAYGDC CKDCRFLPGG TLCRGKTSEC
     DVPEYCNGSS QFCQPDVFIQ NGYPCQNNKA YCYNGMCQYY DAQCQVIFGS KAKAAPKDCF
     IEVNSKGDRF GNCGFSGNEY KKCATGNALC GKLQCENVQE IPVFGIVPAI IQTPSRGTKC
     WGVDFQLGSD VPDPGMVNEG TKCGAGKICR NFQCVDASVL NYDCDVQKKC HGHGVCNSNK
     NCHCENGWAP PNCETKGYGG SVDSGPTYNE TNTALRDGLL VFFFLIVPLI VCAIFIFIKR
     DQLWRSYFRK KRSQTYESDG KNQANPSRQP GSVPRHVSPV TPPREVPIYA NRFPVPTYAA
     KQPQQFPSRP PPPQPKVSSQ GNLIPARPAP APPLYSSLT
//
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