ID A0A2I3GEV4_NOMLE Unreviewed; 403 AA.
AC A0A2I3GEV4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Protein maelstrom homolog {ECO:0000256|ARBA:ARBA00021076};
GN Name=MAEL {ECO:0000313|Ensembl:ENSNLEP00000029850.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000029850.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000029850.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000029850.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a central role during spermatogenesis by repressing
CC transposable elements and preventing their mobilization, which is
CC essential for the germline integrity. Acts via the piRNA metabolic
CC process, which mediates the repression of transposable elements during
CC meiosis by forming complexes composed of piRNAs and Piwi proteins and
CC governs the methylation and subsequent repression of transposons. Its
CC association with piP-bodies suggests a participation in the secondary
CC piRNAs metabolic process. Required for the localization of germ-cell
CC factors to the meiotic nuage. {ECO:0000256|ARBA:ARBA00025698}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the maelstrom family.
CC {ECO:0000256|ARBA:ARBA00007057}.
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DR EMBL; ADFV01184385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003258858.1; XM_003258810.3.
DR AlphaFoldDB; A0A2I3GEV4; -.
DR Ensembl; ENSNLET00000045207.1; ENSNLEP00000029850.1; ENSNLEG00000014771.2.
DR GeneID; 100598064; -.
DR CTD; 84944; -.
DR GeneTree; ENSGT00390000003645; -.
DR OrthoDB; 5394659at2759; -.
DR Proteomes; UP000001073; Chromosome 12.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0060964; P:regulation of miRNA-mediated gene silencing; IEA:InterPro.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR024970; Maelstrom.
DR InterPro; IPR039259; Protein_maelstrom.
DR PANTHER; PTHR21358; PROTEIN MAELSTROM HOMOLOG; 1.
DR PANTHER; PTHR21358:SF4; PROTEIN MAELSTROM HOMOLOG; 1.
DR Pfam; PF09011; HMG_box_2; 1.
DR Pfam; PF13017; Maelstrom; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158}.
FT DOMAIN 2..44
FT /note="HMG box"
FT /evidence="ECO:0000259|Pfam:PF09011"
FT DOMAIN 99..295
FT /note="Maelstrom"
FT /evidence="ECO:0000259|Pfam:PF13017"
FT REGION 326..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 45515 MW; 7935EDC94C1B66CC CRC64;
MPNRKASRNA YYFFVQEKIP ELRRRGLPVA RVADAIPYCS ADWAKPVFTP LRKPGMLVPK
QNVSPPDMTT LSLKGDQALL GGIFYFLNIV SHGELPPHCE QRFLPCEIGC VKYSLQEGIM
ADFHSFINPG EIPRGFRFHC QAASDSSHKI PISNFERGHN QATVLQNLYR FIHPNPGNWP
PIYCKSDDRT RVNWCLKHMA KASEIRQDLQ LLTVEDLVVG IYQQKFLKEP SKTWIRSLLD
VAMWDYSSNT RCKWHEENDI LFCALAVCKK IAYCISNSLA TLFGIQLTEA HVPLQDYEAS
NSVTPKMVVL DAGRYQKLRV GSSGFSHFNS SNQEQRSNTP TGDYPSRAKI SGQNSSVRGR
GITRLLESIS NSSSNIHKFS NCDTSLSPYM SQKDGYKSFS SLS
//
