ID   A0A2I3GF36_NOMLE        Unreviewed;      1071 AA.
AC   A0A2I3GF36;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=IQ motif containing GTPase activating protein 2 {ECO:0000313|Ensembl:ENSNLEP00000029936.1};
GN   Name=IQGAP2 {ECO:0000313|Ensembl:ENSNLEP00000029936.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000029936.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000029936.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000029936.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; ADFV01197508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01197509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01197510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01197511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01197512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01197513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01197514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01197515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01197516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01197517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012360929.1; XM_012505475.1.
DR   AlphaFoldDB; A0A2I3GF36; -.
DR   Ensembl; ENSNLET00000060251.1; ENSNLEP00000029936.1; ENSNLEG00000012573.3.
DR   GeneTree; ENSGT00950000183076; -.
DR   Proteomes; UP000001073; Chromosome 2.
DR   Gene3D; 1.20.5.190; -; 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR000593; RasGAP_C.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001202; WW_dom.
DR   PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR   PANTHER; PTHR14149:SF12; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2; 1.
DR   Pfam; PF00612; IQ; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   Pfam; PF03836; RasGAP_C; 1.
DR   SMART; SM00015; IQ; 2.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF143885; RGC domain-like; 1.
DR   PROSITE; PS50096; IQ; 2.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT   DOMAIN          147..180
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   DOMAIN          413..646
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   COILED          907..934
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1071 AA;  123009 MW;  E3902418628FB31C CRC64;
     MGYFKGVVAV GYINEAIDEG NPLRTLETLL LPTANISDVD PAHAQHYQDV LYHAKSQKLR
     DSESVSKVLW LDEIQQAVDE ANVDEDRAKQ WVTLVVDVNQ CLEGNKSSDI LSVLKSSTSN
     ANDIIPECAD KYYDALVKAK ELKSERVSSE GSWLKLNLHE KYDYYYNIDS KESSWVTPES
     CLYKESWLTG KEIEAFWKGY KQQKEYMHRR QMFIDNTDSI VKIQSWFRMA TARKSYLSRL
     QYFRDHNNEI VKIQSLLRAN KARDDYKTLV GSENPPLTVI RKFVYLLDQS DLDFQEELEV
     ARLREEVVTK IRANQQLEKD LNLMDIKIGL LVKNRITLED VISHSKKLNK KKGGEMEILS
     NTDNQGIKSL SKERRKILET YQQLFYLLQT NPLYLAKLIF QMPQNKSTKF MDTVIFTLYN
     YASNQREEYL LLKLFKTALE EEIKSKVDQV QDIVTGNPTV IKMVVSFNRG ARGQNTLRQL
     LAPVVKEIID DKSLIINTNP VEVYKAWVNQ LETQTGEASK LPYDVTTEQA LTYPEVKNKL
     EASIENLRRV TDKVLNSIIS SLDLLPYGLR YIAKVLKNSI HEKFPDATED ELLKIVGNLL
     YYRYMNPAIV APDGFDIIDM TAGGQINSDQ RRNLGSVAKV LQHAASNKLF EGENEHLSSM
     NNYLSETYQE FRKYFKEACN VPEPEEKFNM DKYTDLVTVS KPVIYISIEE IISTHSLLLE
     HQDAIAPEKN DLLSELLGSL GEVPTVESFL GEGAVDPNDP NKANTLSQLS KTEISLVLTS
     KYDIEDGEAI DSRSLMIKTK KLIIDVIRNQ PGNTLTEILE TPATAQQEVD HATDMVSRAM
     IDSRTPEEMK HSQSMIEDAQ LPLEQKKRKI QRNLRTLEQT GHVSSENKYQ DILNEIAKDI
     RNQRIYRKLR KAELAKLQQT LNALNKKAAF YEEQINYYDT YIKTCLDNLK RKNTRRSIKL
     DGKGEPKGVK RAKPVKYTAA KLHEKGVLLD IDDLQTNQFK NVTFDIIATE DVGIFDVRSK
     FLGVEMEKVQ LNIQDLLQMQ YEGVAVMKMF DKVKVNVNLL IYLLNKKFYG K
//