ID A0A2I3GFD8_NOMLE Unreviewed; 244 AA.
AC A0A2I3GFD8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=cAMP-responsive element modulator {ECO:0000256|ARBA:ARBA00039496};
GN Name=CREM {ECO:0000313|Ensembl:ENSNLEP00000029994.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000029994.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000029994.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000029994.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the bZIP family.
CC {ECO:0000256|ARBA:ARBA00007163}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01091290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01091291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01091292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01091293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01091294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01091295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003276070.1; XM_003276022.2.
DR AlphaFoldDB; A0A2I3GFD8; -.
DR Ensembl; ENSNLET00000042867.1; ENSNLEP00000029994.1; ENSNLEG00000018140.3.
DR GeneTree; ENSGT00940000156952; -.
DR Proteomes; UP000001073; Chromosome 18.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd14690; bZIP_CREB1; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR003102; CREB1-like_pKID.
DR InterPro; IPR001630; Leuzip_CREB.
DR PANTHER; PTHR45879:SF4; CAMP-RESPONSIVE ELEMENT MODULATOR; 1.
DR PANTHER; PTHR45879; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR Pfam; PF02173; pKID; 1.
DR PRINTS; PR00041; LEUZIPPRCREB.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
DR PROSITE; PS50953; KID; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..59
FT /note="KID"
FT /evidence="ECO:0000259|PROSITE:PS50953"
FT DOMAIN 186..237
FT /note="BZIP"
FT /evidence="ECO:0000259|PROSITE:PS50217"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 41..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 211..238
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 244 AA; 26363 MW; 1C69B0C53AEE4C5D CRC64;
MVATIAETDE SAESEGVIDS HKRREILSRR PSYRKILNEL SSDVPGVPKI EEERSEEEGT
PPNIATMAVP TSIYQTSTGQ YIAVAQGGTI QISNPGSDGV QGLQALTMTN SGAPPPGATI
VQYAAQSADG TQQFFVPGSQ VVVQAATGDM PAYQIRAPTA ALPQGVVMAA SPGSLHSPQQ
LAEEATRKRE LRLMKNREAA KECRRRKKEY VKCLESRVAV LEVQNKKLIE ELETLKDICS
PKTD
//
