ID A0A2I3GHC1_NOMLE Unreviewed; 771 AA.
AC A0A2I3GHC1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=TLE family member 3, transcriptional corepressor {ECO:0000313|Ensembl:ENSNLEP00000030706.1};
GN Name=TLE3 {ECO:0000313|Ensembl:ENSNLEP00000030706.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000030706.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000030706.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000030706.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR EMBL; ADFV01036146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01036147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01036148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GHC1; -.
DR Ensembl; ENSNLET00000049008.1; ENSNLEP00000030706.1; ENSNLEG00000013552.3.
DR GeneTree; ENSGT01030000234519; -.
DR Proteomes; UP000001073; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF24; TRANSDUCIN-LIKE ENHANCER PROTEIN 3; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 21..130
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 571..612
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 613..654
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 127..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 29..63
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 138..152
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 771 AA; 82953 MW; 7EC6346A8A4927AA CRC64;
PPPPPPRPLL QAPHQPGQPG FKFTVVESCD RIKDEFQFLQ AQYHSLKVEY DKLANEKTEM
QRHYVMLHVV SLPLQTEIAK RLNTILAQIM PFLSQEHQQQ VAQAVERAKQ VTMTELNAII
GQQQLQAQHL SHATHGPPVQ LPPHPSGLQP PGIPPVTGSS SGLLALGALG SQAHLTVKDE
KNHHELDHRE RESSAVSNNS VSPSESLRAS EKHRGSADYS MEAKKRKAEE KDSLSRYDSD
GDKSDDLVVD VSNEDPATPR VSPAHSPPEN GLDKARSLKK DAPTSPASVA SSSSTPSSKT
KDLGHNDKSS TPGLKSNTPT PRNDAPTPGT STTPGLRSMP GKPPGMDPIG IMASALRTPI
SITSSYAAPF AMMSHHEMNG SLTSPGAYAG LHNIPPQMSA AAAAAAAAYG RSPMVSFGAV
GFDPHPPMRA TGLPSSLASI PGGKPAYSFH VSADGQMQPV PFPHDALAGP GIPRHARQIN
TLSHGEVVCA VTISNPTRHV YTGGKGCVKI WDISQPGSKS PISQLDCLNR DNYIRSCKLL
PDGRTLIVGG EASTLTIWDL ASPTPRIKAE LTSSAPACYA LAISPDAKVC FSCCSDGNIA
VWDLHNQTLV RQFQGHTDGA SCIDISHDGT KLWTGGLDNT VRSWDLREGR QLQQHDFTSQ
IFSLGYCPTG EWLAVGMESS NVEVLHHTKP DKYQLHLHES CVLSLKFAYC GKWFVSTGKD
NLLNAWRTPY GASIFQSKES SSVLSCDISA DDKYIVTGSG DKKATVYEVI Y
//
