ID A0A2I3GK50_NOMLE Unreviewed; 532 AA.
AC A0A2I3GK50;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Cleavage and polyadenylation-specific factor 3-like protein {ECO:0000256|ARBA:ARBA00029625};
GN Name=INTS11 {ECO:0000313|Ensembl:ENSNLEP00000031637.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000031637.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000031637.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000031637.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
CC {ECO:0000256|ARBA:ARBA00007093}.
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DR EMBL; ADFV01120207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01120208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01120209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01120210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01120211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GK50; -.
DR STRING; 61853.ENSNLEP00000031637; -.
DR Ensembl; ENSNLET00000056977.1; ENSNLEP00000031637.1; ENSNLEG00000000053.3.
DR GeneTree; ENSGT00940000157644; -.
DR InParanoid; A0A2I3GK50; -.
DR OMA; YLDGMIW; -.
DR Proteomes; UP000001073; Chromosome 24.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0032039; C:integrator complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:Ensembl.
DR GO; GO:0016180; P:snRNA processing; IEA:Ensembl.
DR CDD; cd16291; INTS11-like_MBL-fold; 1.
DR Gene3D; 3.40.50.10890; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR022712; Beta_Casp.
DR InterPro; IPR041897; INTS11-like_MBL-fold.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR011108; RMMBL.
DR PANTHER; PTHR11203; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11203:SF37; INTEGRATOR COMPLEX SUBUNIT 11; 1.
DR Pfam; PF10996; Beta-Casp; 1.
DR Pfam; PF16661; Lactamase_B_6; 1.
DR Pfam; PF07521; RMMBL; 1.
DR SMART; SM01027; Beta-Casp; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 22..247
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
FT DOMAIN 248..366
FT /note="Beta-Casp"
FT /evidence="ECO:0000259|SMART:SM01027"
SQ SEQUENCE 532 AA; 59704 MW; D1C0596BA8F25C70 CRC64;
ICGAGFGHFT WLAGGGAGQD VGRSCILVSI AGKNVMLDCG MHMGFNDDRR FPDFSYITQN
GRLTDFLDCV IISHFHLDHC GALPYFSEMV GYDGPIYMTH PTQAICPILL EDYRKIAVDK
KGEANFFTSQ MIKDCMKKVV AVHLHQTVQV DDELEIKAYY AGHVLGAAMF QIKVGSESVV
YTGDYNMTPD RHLGAAWIDK CRPNLLITES TYATTIRDSK RCRERDFLKK VHETVERGAD
TRVALGRAQE LCILLETFWE RMNLKVPIYF STGLTEKANH YYKLFIPWTN QKIRKTFVQR
NMFEFKHIKA FDRAFADNPG PMVVFATPGM LHAGQSLQIF RKWAGNEKNM VIMPGYCVQG
TVGHKILSGQ RKLEMEGRQV LEVKMQVEYM SFSAHADAKG IMQLVGQAEP ESVLLVHGEA
KKMEFLKQKI EQELRVSCYM PANGETVTLP TSPSIPVGIS LGLLKREMAQ GLLPEAKKPR
LLHGTLIMKD SVRGRAAAAL PDLSLWVWLS TSCASPASVH LHDTRKEQET AL
//
