ID A0A2I3GLC8_NOMLE Unreviewed; 630 AA.
AC A0A2I3GLC8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Lymphocyte cytosolic protein 1 {ECO:0000313|Ensembl:ENSNLEP00000032128.1};
GN Name=LCP1 {ECO:0000313|Ensembl:ENSNLEP00000032128.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000032128.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000032128.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000032128.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01053363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01053364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01053365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GLC8; -.
DR STRING; 61853.ENSNLEP00000032128; -.
DR Ensembl; ENSNLET00000037883.1; ENSNLEP00000032128.1; ENSNLEG00000002616.3.
DR GeneTree; ENSGT00950000183097; -.
DR InParanoid; A0A2I3GLC8; -.
DR OMA; WQLMRKN; -.
DR Proteomes; UP000001073; Chromosome 5.
DR GO; GO:0005884; C:actin filament; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030175; C:filopodium; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0001891; C:phagocytic cup; IEA:Ensembl.
DR GO; GO:0002102; C:podosome; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0001725; C:stress fiber; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0051020; F:GTPase binding; IEA:Ensembl.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0051017; P:actin filament bundle assembly; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0022617; P:extracellular matrix disassembly; IEA:Ensembl.
DR GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl.
DR GO; GO:0010737; P:protein kinase A signaling; IEA:Ensembl.
DR GO; GO:0033157; P:regulation of intracellular protein transport; IEA:Ensembl.
DR GO; GO:0002286; P:T cell activation involved in immune response; IEA:Ensembl.
DR CDD; cd21327; CH_PLS2_rpt2; 1.
DR CDD; cd21333; CH_PLS2_rpt4; 1.
DR CDD; cd21292; CH_PLS_rpt1; 1.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039959; Fimbrin/Plastin.
DR PANTHER; PTHR19961; FIMBRIN/PLASTIN; 1.
DR PANTHER; PTHR19961:SF35; PLASTIN-2; 1.
DR Pfam; PF00307; CH; 4.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00033; CH; 4.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 2.
DR PROSITE; PS50021; CH; 4.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 12..47
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 52..87
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 123..239
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 267..378
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 397..506
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 518..627
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
SQ SEQUENCE 630 AA; 70635 MW; D9682027BB3479A6 CRC64;
MDGWDVGSVS DEEMMELREA FAKVDTDGNG YISFNELNDL FKAACLPLPG YRVREITENL
MATGDLDQDG RISFDEFIKI FHGLKSTDVA KTFRKAINKK EGICAIGGTS EQSSVGTQHS
YSEEEKYAFV NWINKALEND PDCRHVIPMN PNTNDLFNAV GDGIVLCKMI NLSVPDTIDE
RTINKKKLTP FTIQENLNLA LNSASAIGCH VVNIGAEDLK EGKPYLVLGL LWQVIKIGLF
ADIELSRNEA LIALLREGES LEDLMKLSPE ELLLRWANYH LENAGCNKIG NFSTDIKDSK
AYYHLLEQVA PKGDEEGVPA VVIDMSGLRE KDDIQRAECM LQQAERLGCR QFVTATDVVR
GNPKLNLAFI ANLFNRYPAL HKPENQDIDW GALEGETREE RTFRNWMNSL GVNPRVNHLY
SDLSDALVIF QLYEKIKVPV DWNRVNKPPY PKLGGNMKKL ENCNYAVELG KNQAKFSLVG
IGGQDLNEGN RTLTLALIWQ LMRRYTLNIL EEIGGGQKVN DDIIVNWVNE TLREAEKSSS
ISSFKDPKIS TSLPVLDLID AIQPGSINYD LLKTENLNDD EKLNNAKYAI SMARKIGARV
YALPEDLVEV NPKMVMTVFA CLMGKGMKRV
//
