ID A0A2I3GLP0_NOMLE Unreviewed; 666 AA.
AC A0A2I3GLP0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Protein phosphatase 2 scaffold subunit Abeta {ECO:0000313|Ensembl:ENSNLEP00000032239.1};
GN Name=PPP2R1B {ECO:0000313|Ensembl:ENSNLEP00000032239.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000032239.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000032239.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000032239.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01056531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01056532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01056533; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01056534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01056535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01056536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GLP0; -.
DR STRING; 61853.ENSNLEP00000032239; -.
DR Ensembl; ENSNLET00000047686.1; ENSNLEP00000032239.1; ENSNLEG00000007268.3.
DR GeneTree; ENSGT00950000183066; -.
DR InParanoid; A0A2I3GLP0; -.
DR OMA; NRVEAMQ; -.
DR Proteomes; UP000001073; Chromosome 15.
DR GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR GO; GO:0060561; P:apoptotic process involved in morphogenesis; IEA:Ensembl.
DR GO; GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR PANTHER; PTHR10648; SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10648:SF9; SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A BETA ISOFORM; 1.
DR Pfam; PF02985; HEAT; 6.
DR Pfam; PF13646; HEAT_2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 12.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 24..62
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 101..139
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 178..216
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 217..255
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 256..294
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 295..332
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 338..376
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 377..415
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 416..454
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 494..532
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 533..571
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 572..607
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REGION 611..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 666 AA; 73574 MW; 9CD2EBC6FB19EB89 CRC64;
MAGASGLGTG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI ALALGVERTR
SELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC LLPPLENLAT VEETVVRDKA
VESLRQISQE HTPVALEAYF VPLVKRLASG DWFTSRTSAC GLLSVCYPRA SNAVKAEIRR
QFRSLCSDDT PMVRRAAASK LGEFAKVLEL DSVKSEIVPL FTNLASDEQD SVRLLAVEAC
VSIAQLLPQD DLETLVMPTL RQAAEDKSWR VRYMVADKFS ELQKAMGPKI TLNDLIPAFQ
NLLKDCEAEV RAAAAHKVKE LGENLSIEDR ETIIMNQILP YIKELVSDTS QHVKSALASV
IMGLSTILGK ENTIEHLLPL FLAQLKDECP EVRLNIISNL DCVNEVIGIR QLSQSLLPAI
VELAEDAKWR VRLAIIEYMP LLAGQLGVEF FDEKLNSLCM AWLVDHVYAI REAATNNLMK
LVQKFGTEWA QNTIVPKVLV MANDPNYLHR MTTLFCINAL SEACGQEITT KQMLPIVLKM
AGDQVANVRF NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVVAQ
RLRKLDFPVK DSREPSVPRA DKNHFPRPRV PGEDTAKGPV YQLHGDNRDT LALEIAELVR
FSQSTD
//
