ID A0A2I3GLP2_NOMLE Unreviewed; 99 AA.
AC A0A2I3GLP2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=High mobility group nucleosome-binding domain-containing protein 3 {ECO:0000256|ARBA:ARBA00022145};
GN Name=HMGN3 {ECO:0000313|Ensembl:ENSNLEP00000032177.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000032177.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000032177.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000032177.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Binds to nucleosomes, regulating chromatin structure and
CC consequently, chromatin-dependent processes such as transcription, DNA
CC replication and DNA repair. Affects both insulin and glucagon levels
CC and modulates the expression of pancreatic genes involved in insulin
CC secretion. Regulates the expression of the glucose transporter SLC2A2
CC by binding specifically to its promoter region and recruiting PDX1 and
CC additional transcription factors. Regulates the expression of SLC6A9, a
CC glycine transporter which regulates the glycine concentration in
CC synaptic junctions in the central nervous system, by binding to its
CC transcription start site. May play a role in ocular development and
CC astrocyte function. {ECO:0000256|ARBA:ARBA00025168}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HMGN family.
CC {ECO:0000256|ARBA:ARBA00007696}.
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DR EMBL; ADFV01180056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012352486.1; XM_012497032.1.
DR AlphaFoldDB; A0A2I3GLP2; -.
DR Ensembl; ENSNLET00000056441.1; ENSNLEP00000032177.1; ENSNLEG00000028556.1.
DR GeneID; 100593719; -.
DR CTD; 9324; -.
DR GeneTree; ENSGT00950000182802; -.
DR OrthoDB; 4616133at2759; -.
DR Proteomes; UP000001073; Chromosome 18.
DR GO; GO:0000785; C:chromatin; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031492; F:nucleosomal DNA binding; IEA:InterPro.
DR InterPro; IPR000079; HMGN_fam.
DR PANTHER; PTHR23087:SF2; HIGH MOBILITY GROUP NUCLEOSOME-BINDING DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR23087; NONHISTONE CHROMOSOMAL PROTEIN HMG; 1.
DR Pfam; PF01101; HMG14_17; 1.
DR PRINTS; PR00925; NONHISHMG17.
DR SMART; SM00527; HMG17; 1.
DR PROSITE; PS00355; HMG14_17; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT REGION 1..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 99 AA; 10691 MW; B66EF00FF88B9C21 CRC64;
MPKRKSPENT EGKDGSKVTK QEPTRRSARL SAKPPPPKPE PKPRKTSAKK EPGAKISRGA
KGKKEEKQEA GKEGTAPSEN GETKAEEAQK TESVDNKGE
//
