ID A0A2I3GMQ0_NOMLE Unreviewed; 538 AA.
AC A0A2I3GMQ0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RGS domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=RGS6 {ECO:0000313|Ensembl:ENSNLEP00000032591.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000032591.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000032591.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000032591.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01017365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01017366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01017367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01017368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01017369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01017370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01017371; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01017372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01017373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01017374; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GMQ0; -.
DR STRING; 61853.ENSNLEP00000032591; -.
DR Ensembl; ENSNLET00000051952.1; ENSNLEP00000032591.1; ENSNLEG00000002297.3.
DR GeneTree; ENSGT00940000157159; -.
DR InParanoid; A0A2I3GMQ0; -.
DR Proteomes; UP000001073; Chromosome 1a.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR CDD; cd00068; GGL; 1.
DR CDD; cd08737; RGS_RGS6; 1.
DR Gene3D; 1.10.1240.60; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR047016; RGS6/7/9/11.
DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR InterPro; IPR037956; RGS6_RGS.
DR InterPro; IPR040759; RGS_DHEX.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45746; LP21163P; 1.
DR PANTHER; PTHR45746:SF2; REGULATOR OF G-PROTEIN SIGNALING 6; 1.
DR Pfam; PF00631; G-gamma; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF18148; RGS_DHEX; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT DOMAIN 1..46
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 267..382
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 433..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..531
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 538 AA; 61834 MW; 6B51E3528472D2F7 CRC64;
MKNLSIEDPV EAIHLGSLIA AQGYIFPISD HVLTMKDDGT FYRFQAPYFW PSNCWEPENT
DYAIYLCKRT MQNKARLELA DYEAENLARL QRAFARKWEF IFMQAEAQVK IDRKKDKTER
KILDSQERAF WDVHRPVPGC VNTTEMDIRK CRRLKNPQKV KKSVYGVTEE SQAQSPVHVL
SQPIRKTTKE DIRKQITFLN AQIDRHCLKM SKVAESLIAY TEQYMEYDPL ITPAEPSNPW
ISDDVALWDI EMSKEPSQQR VKRWGFSFDE ILKDQVGRDQ FLRFLESEFS SENLRFWLAV
QDLKKQPLQD VAKRVEEIWQ EFLAPGAPSA INLDSHSYEI TSQNVKDGGR YTFEDAQEHI
YKLMKSDSYA RFLRSNAYQD LLLAKKKPES EQGRRTSLEK FTRSVNVQNT RPASASSIFM
AGLMATGLHT PRSCHGLSES RPLGLPSLHD GLREGQSLPQ SYLGSSSTAA EGARERASNG
RSLARQQHCQ CQGQGEETQL CLWSRLASSK RSQRASSLRT SKAKKKRQTV KQGLKAWP
//
