ID A0A2I3GNA2_NOMLE Unreviewed; 1652 AA.
AC A0A2I3GNA2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Polybromo 1 {ECO:0000313|Ensembl:ENSNLEP00000032823.1};
GN Name=PBRM1 {ECO:0000313|Ensembl:ENSNLEP00000032823.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000032823.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000032823.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000032823.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; ADFV01173455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000042142.1; ENSNLEP00000032823.1; ENSNLEG00000007161.3.
DR GeneTree; ENSGT00390000003017; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0016586; C:RSC-type complex; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR CDD; cd04717; BAH_polybromo; 2.
DR CDD; cd05524; Bromo_polybromo_I; 1.
DR CDD; cd05517; Bromo_polybromo_II; 1.
DR CDD; cd05520; Bromo_polybromo_III; 1.
DR CDD; cd05518; Bromo_polybromo_IV; 1.
DR CDD; cd05515; Bromo_polybromo_V; 1.
DR CDD; cd05526; Bromo_polybromo_VI; 1.
DR CDD; cd21984; HMG-box_PB1; 1.
DR Gene3D; 2.30.30.490; -; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 6.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR037968; PBRM1_BD5.
DR InterPro; IPR037382; Rsc/polybromo.
DR PANTHER; PTHR16062:SF19; PROTEIN POLYBROMO-1; 1.
DR PANTHER; PTHR16062; SWI/SNF-RELATED; 1.
DR Pfam; PF01426; BAH; 2.
DR Pfam; PF00439; Bromodomain; 6.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00439; BAH; 2.
DR SMART; SM00297; BROMO; 6.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47370; Bromodomain; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS51038; BAH; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 5.
DR PROSITE; PS50014; BROMODOMAIN_2; 6.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 64..134
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 200..270
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 400..470
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 553..623
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 691..761
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 832..877
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 971..1089
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1171..1287
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1394..1462
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 1394..1462
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1121..1148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1369..1393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..654
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..948
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1652 AA; 189645 MW; 678F8308AE2A84C9 CRC64;
MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY
KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK LKMEEYDDVN LLTADFQLLF
NNAKAYYKPD SPEYKAACKL WDLYLRTRNE FVQKGEADDE DDDEDGQDNQ GTVTEGSSPT
YLKEILEQLL EAIVVATNPS GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG
SYKSIHAMAK DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR
TPSNLAAARL TGPSHSKGSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ YGSESEEDAA
LAAARYEEGE SEAESITSFM DVSNPFYQLY DTVRSCRNNQ GQLIAEPFFH LPSKKKYPDY
YQQIKMPISL QQIRTKLKNQ EYETLDHLEC DLNLMFENAK RYNVPNSAIY KRVLKLQQVM
QAKKKELARR DDIEDGDSMI SSATSDTGSA KRKRNTHDSE MLGLRRLSSK KNIRKQRMKI
LFNVVLEARE PGSGRRLCDL FMVKPSKKDY PDYYKIILEP MDLKIIEHNI RNDKYAGEEG
MIEDMKLMFR NARHYNEEGS QVYNDAHILE KLLKEKRKEL GPLPDDDDMA SPKLKLSRKS
GISPKKSKYM TPMQQKLNEV YEAVKNYTDK RGRRLSAIFL RLPSRSELPD YYLTIKKPMD
MEKIRSHMMA NKYQDIDSMV EDFVMMFNNA CTYNEPESLI YKDALVLHKV LLETRRDLEG
DEDSHVPNVT LLIQELIHNL FVSVMSHQDD EGRCYSDSLA EIPAVDPNFP NKPPLTFDII
RKNVENNRYR RLDLFQEHMF EVLERARRMN RTDSEIYEDA VELQQFFIKI RDELCKNGEI
LLSPALSYTT KHLHNDVEKE KKEKLPKEIE EDKLKREEEK REAEKSEDSS GTAGLSGLHR
TYSQDCSFKN SMYHVGDYVY VEPAEANLQP HIVCIERLWE DSAGEKWLYG CWFYRPNETF
HLATRKFLEK EVFKSDYYNK VPVSKILGKC VVMFVKEYFK LCPENFRDED VFVCESRYSA
KTKSFKKIKL WTMPISSVRF VPRDVPLPVV RVASVFANAD KGDDEKNTDN SEDSRAEDNF
NLEKEKEDVP VEMSNGEPGC HYFEQLHYND MWLKVGDCVF IKSHGLVRPR VGRIEKVWVR
DGAAYFYGPI FIHPEETEHE PTKMFYKKEV FLSNLEETCP MTCILGKCAV LSFKDFLSCR
PTEIPENDIL LCESRYNESD KQMKKFKGLK RFSLSAKVVD DEIYYFRKPI VPQKEPSPLL
EKKIQLLEAK FAELEGGDDD IEEMGEEDSE VIEPPSLPQL QTPLASELDL MPYTPPQSTP
KSAKGSAKKE GSKRKINMSG YILFSSEMRA VIKAQHPDYS FGELSRLVGT EWRNLETAKK
AEYEERAAKV AEQQERERAA QQQQPSASPR AGTPVGALMG VVPPPTPMGM LNQQLTPVAG
VMNQGVAPMV GTPAPGGSPY GQQVGVLGPP GQQAPPPYPG PHPAGPPVIQ QPTTPMFVAP
PPKTQRLLHS EAYLKYIEGL SAESNSISKW DQTLAARRRD VHLSKEQESR LPSHWLKSKG
AHTTMADALW RLRDLMLRDT LNIRQAYNLE NV
//
