GenomeNet

Database: UniProt
Entry: A0A2I3GNE0_NOMLE
LinkDB: A0A2I3GNE0_NOMLE
Original site: A0A2I3GNE0_NOMLE 
ID   A0A2I3GNE0_NOMLE        Unreviewed;       150 AA.
AC   A0A2I3GNE0;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Bis(5'-adenosyl)-triphosphatase {ECO:0000256|RuleBase:RU366076};
DE            EC=3.6.1.29 {ECO:0000256|RuleBase:RU366076};
GN   Name=FHIT {ECO:0000313|Ensembl:ENSNLEP00000032826.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000032826.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000032826.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000032826.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate = ADP + AMP + 2
CC         H(+); Xref=Rhea:RHEA:13893, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58529, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216;
CC         EC=3.6.1.29; Evidence={ECO:0000256|RuleBase:RU366076};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|RuleBase:RU366076};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ADFV01077688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01077689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01077690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01077691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01077692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01077693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01077694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01077695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01077696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01077697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2I3GNE0; -.
DR   STRING; 61853.ENSNLEP00000032826; -.
DR   Ensembl; ENSNLET00000039344.1; ENSNLEP00000032826.1; ENSNLEG00000033239.1.
DR   GeneTree; ENSGT00510000047967; -.
DR   InParanoid; A0A2I3GNE0; -.
DR   OMA; HSYGFVN; -.
DR   Proteomes; UP000001073; Chromosome 21.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0043530; F:adenosine 5'-monophosphoramidase activity; IEA:Ensembl.
DR   GO; GO:0047627; F:adenylylsulfatase activity; IEA:Ensembl.
DR   GO; GO:0047352; F:adenylylsulfate-ammonia adenylyltransferase activity; IEA:Ensembl.
DR   GO; GO:0047710; F:bis(5'-adenosyl)-triphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR   GO; GO:0015964; P:diadenosine triphosphate catabolic process; IEA:Ensembl.
DR   GO; GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
DR   GO; GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   GO; GO:0006163; P:purine nucleotide metabolic process; IEA:Ensembl.
DR   CDD; cd01275; FHIT; 1.
DR   Gene3D; 3.30.428.10; HIT-like; 1.
DR   InterPro; IPR039383; FHIT.
DR   InterPro; IPR019808; Histidine_triad_CS.
DR   InterPro; IPR011146; HIT-like.
DR   InterPro; IPR036265; HIT-like_sf.
DR   PANTHER; PTHR46981; BIS(5'-ADENOSYL)-TRIPHOSPHATASE; 1.
DR   PANTHER; PTHR46981:SF1; BIS(5'-ADENOSYL)-TRIPHOSPHATASE; 1.
DR   Pfam; PF01230; HIT; 1.
DR   SUPFAM; SSF54197; HIT-like; 1.
DR   PROSITE; PS00892; HIT_1; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|RuleBase:RU366076};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU366076};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT   DOMAIN          2..109
FT                   /note="HIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51084"
FT   MOTIF           94..98
FT                   /note="Histidine triad motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT   ACT_SITE        96
FT                   /note="Tele-AMP-histidine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-1"
FT   BINDING         8
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT   BINDING         27
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT   BINDING         83
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT   BINDING         89..92
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT   BINDING         98
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT   SITE            114
FT                   /note="Important for induction of apoptosis"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-3"
SQ   SEQUENCE   150 AA;  17142 MW;  893E78CC09429BBC CRC64;
     MSFRFGQHLI KPSAVFLKTE LSFAFVNRKP VVPGHVLVCP LRPVERFRDL RTDEVADLFQ
     ATQRVGTVVE KHFHGTSVTF SMQDGPEAGQ TVKHVHVHVL PRKAGDFHRN DSIYEELQKH
     DKEEEDSPAS CRSEEEMAAE AVALRVYFQR
//
DBGET integrated database retrieval system