ID A0A2I3GNJ2_NOMLE Unreviewed; 2015 AA.
AC A0A2I3GNJ2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Calcium voltage-gated channel subunit alpha1 I {ECO:0000313|Ensembl:ENSNLEP00000032894.1};
GN Name=CACNA1I {ECO:0000313|Ensembl:ENSNLEP00000032894.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000032894.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000032894.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000032894.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01024717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000042423.1; ENSNLEP00000032894.1; ENSNLEG00000015272.3.
DR GeneTree; ENSGT00940000158594; -.
DR Proteomes; UP000001073; Chromosome 7b.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR005445; VDCC_T_a1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF209; VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR01629; TVDCCALPHA1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 192..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 711..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 753..769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1098..1116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1136..1157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1169..1195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1233..1255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1334..1358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1414..1431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1451..1470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1534..1561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1636..1657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 154..392
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 589..817
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1096..1368
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1414..1667
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1684..1711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1793..1816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1930..2015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1367..1394
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 516..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..553
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..980
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1930..1953
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1985..2003
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2015 AA; 223498 MW; 25E79F641593C71F CRC64;
MAESASPPSS SAAAPAAEPG VTTEQPGPRS PPSSPPGLEE PLDGADPHVP HPDLAPVAFF
CLRQTTSPRN WCIKMVCNPY PPQPRLIGAL FLSQLNHCVI LGKSCPLWAF IFIAIKWGVI
MSAMPVSQGS CGHRWNKEGM RFKSWMVEYS LDLQNINLSA IRTVRVLRPL KAINRVPSMR
ILVNLLLDTL PMLGNVLLLC FFVFFIFGII GVQLWAGLLR NRCFLEENFT IQGDVALPPY
YQPEEDDEMP FICSLSGDNG IMGCHEIPPL KEQGRECCLS KDDVYDFGAG RQDLNASGLC
VNWNRYYNVC RTGSANPHKG AINFDNIGYA WIVIFQVITL EGWVEIMYYV MDAHSFYNFI
YFILLIIVGS FFMINLCLVV IATQFSETKQ REHRLMLEQR QRYLSSSTVA SYAEPGDCYE
EIFQYVCHIL RKAKRRALGL YQALQSRRQA LGPEAPAPAK PGPHAKEPRH YKLCPQHSPL
DVTAHTLVQP IPAMLASDPA SCPCCQHEAG RRPSGLGSTD SGQEGSGSGS STGGEDEADG
DEARSSEDRA SSELGKEEEE EEQADGAVWL CGDVWRETRA KLRGIVDSKY FNRGIMMAIL
VNTVSMGIEH HEQPEELTNI LEICNVVFTS MFALEMILKL AAFGLFDYLR NPYNIFDSII
VIISIWEIVG QADGGLSVLR TFRLLRVLKL VRFMPALRRQ LVVLMKTMDN VATFCMLLML
FIFIFSILGM HIFGCKFSLR TDTGDTVPDR KNFDSLLWAI VTVFQILTQE DWNVVLYNGM
ASTSPWASLY FVALMTFGNY VLFNLLVAIL VEGFQAEGDA NRSYTDEDQS SSNMEEFDKL
QEGLDSSGDP KLCPIPMTPN GHLDPSLPLG GHLGPAGAAG PAPRLSLQPD PMLVALGSRK
SSVMSLGRMS YDQRSLVSPC GELWMGASSK VRQGPCLLHS WVPSARVAAD EGPPRAAPLH
APHTHHAHHG PHLAHRHRHH RRTLSLDNRD SVDLAELVPA VGAHPRAAWR AAGPVPGHED
CNGRMPSIAK DVFTKMGDRG DRGEDEEEID YTLCFRVRKM IDVYKPDWCE VREDWSVYLF
SPENRFRVLC QTIIAHKLFD YVVLAFIFLN CITIALERPQ IEAGSTERIF LTVSNYIFTA
IFVGEMTLKV VSLGLYFGEQ AYLRSSWNVL DGFLVFVSII DIVVSLASAG GAKILGVLRV
LRLLRTLRPL RVISRAPGLK LVVETLISSL KPIGNIVLIC CAFFIIFGIL GVQLFKGKFY
HCLGVDTRNI TNRSDCMAAN YRWVHHKYNF DNLGQALMSL FVLASKDGWV NIMYNGLDAV
AVDQQPVTNH NPWMLLYFIS FLLIVSFFVL NMFVGVVVEN FHKCRQHQEA EEARRREEKR
LRRLEKKRRK AQRLPYYATY CHTRLLIHSM CTSHYLDIFI TFIICLNVVT MSLEHYNQPT
SLETALKYCN YMFTTVFVLE AVLKLVAFGL RRFFKDRWNQ LDLAIVLLSV MGITLEEIEI
NAALPINPTI IRIMRVLRIA RVLKLLKMAT GMRALLDTVV QALPQVGNLG LLFMLLFFIY
AALGVELFGK LVCNDENPCE GMSRHATFEN FGMAFLTLFQ VSTGDNWNGI MKDTLRDCTH
DERSCLSSLQ FVSPLYFVSF VLTAQFVLIN VVVAVLMKHL DDSNKEAQED AEMDAELELE
MAHGLGPGPR LPAGSPGAPG RGPGGAGGGG DTEGGLCRRC YSPAQVGVWT FLTTARSLFR
ASGLWLHAPG PRSAHPNPGV TRGHPLFLQV QLAETEAFSL NSDRSSSILL GDDLSLEDPT
ACPPGPKDSK GELDPPEPMH VGDLGECFFP LSSTAVSPDP ENFLCEMEEI PFNPVRSWLK
HESSQAPPSP FSPDASSPLL PMPAEFFHPA VSASQKGPEK GTGTGTLPKI ALQGSWASLR
SPRVNCTLLR QVPTPPRPQS TGLKFSSTSS LAAPGRPRAA ALAHGLARSP SWAADRSKDP
PGRAPMPMGL GPLAPPPQPL PGELEPGDAA SKRKR
//
