ID A0A2I3GQR2_NOMLE Unreviewed; 1141 AA.
AC A0A2I3GQR2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Tight junction protein 2 {ECO:0000313|Ensembl:ENSNLEP00000033659.1};
GN Name=TJP2 {ECO:0000313|Ensembl:ENSNLEP00000033659.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000033659.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000033659.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000033659.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; ADFV01037752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01037753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01037754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01037755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01037756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01037757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01037758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01037759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01037760; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01037761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GQR2; -.
DR Ensembl; ENSNLET00000048327.1; ENSNLEP00000033659.1; ENSNLEG00000000582.3.
DR GeneTree; ENSGT00940000158634; -.
DR Proteomes; UP000001073; Chromosome 1a.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12027; SH3_ZO-2; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005417; ZO.
DR InterPro; IPR005419; ZO-2.
DR InterPro; IPR035598; ZO-2_SH3.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR PANTHER; PTHR13865:SF26; TIGHT JUNCTION PROTEIN ZO-2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR PRINTS; PR01599; ZONOCCLUDNS2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 37..124
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 312..379
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 503..584
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 598..663
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 768..870
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 156..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..1033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..929
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..962
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1108..1123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1141 AA; 128762 MW; 1EB432D6B3C34C58 CRC64;
MKTAQALHRM WIQAVKKLRR WKGRAPGMEE LIWEQYTVTL QKDSKRGFGI AVSGGRDNPH
FENGETSIVI SDVLPGGPAD GLLQENDRVV MVNGTPMEDV LHSFAVQQLR KSGKVAAIVV
KRPRKVQVAP LQASPPLDQD DRAFEVMDEF DGRSFRSGYS ERSRLSSHGG RSRSWEDSPE
RGRPHDRAWS RERDLSQDRS RGRSLERGLD QDHARARDRS RGRSLERGLD HDFGPSRDRD
RDRSRGRSID QDYERAYHQA YDPDYERLRL PGSRHSPASA SRSSWDYRRP PPHPFFEQID
DIRVCLCVCL LEYGLRLGSQ IFIKEMTRTG LATKDGNLHE GDIILKINGT VTENMSLTDA
RKLIEKSRGK LQLVVLRDSQ QTLINIPSLN DSDSEIEDIS EIESNRSFSP EERRQQYSDY
DYHSSSEKLK ERPSSREDTP SRLSRMGATP TPFKSTGDIA GTVVPETNKE PRYQEDPPAP
QPKAAPRTFL RPSPEDEAIY GPNTKMVRFK KGDSVGLRLA GGNDVGIFVA GIQEGTSAEQ
EGLQEGDQIL KVNTQDFRGL VREDAVLYLL EIPKGEMVTI LAQSRADVYR DILACGRGDS
FFIRSHFECE KETPQSLAFT RGEVFRVVDT LYDGKLGNWL AVRIGNELEK GLIPNKSRAE
QMASVQNAQR DNAGDRADFW RMRGQRSGVK KNLRKSREDL TAVVSVSTKF PAYERVLLRE
AGFKRPVVLF GPIADIAMEK LANELPDLFQ TAKTEPKDAG SEKSTGVVRL NTVRQIIEQD
KHALLDVTPK AVDLLNYTQW FPIVIFFNPD SRQGVKTMRQ RLNPTSNKSS RKLFDQANKL
KKTCAHLFTA TIHLNSANDS WFGSLKDTIQ HQQGEAVWVS EGKELDSEEK QDSLRNADYL
SCDSRLISDF EDTDGEGGAY TDNELDEPAE EPLVSSITRS SEPVQHEEAK PQNKEESYDF
SKSYEYKSNP SAVAGNETPG ASTKGYPPPV AAKPTFGWSI LKPSTPIPPQ EGEEMGESSE
EQDNAPKSVL GKVKIFEKMD HKARLQRMQE LQEAQNARIE IAQKHPDIYA VPIKTHKPDP
GLPQHTSSRP PEPQKAPSRP YQDTRGSYGS DAEEEEYRQQ LSEHSKRGYY GQSARYRDTE
L
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