ID A0A2I3GSI4_NOMLE Unreviewed; 1207 AA.
AC A0A2I3GSI4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=LDL receptor related protein 2 {ECO:0000313|Ensembl:ENSNLEP00000034294.1};
GN Name=LRP2 {ECO:0000313|Ensembl:ENSNLEP00000034294.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000034294.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000034294.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000034294.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; ADFV01058400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GSI4; -.
DR Ensembl; ENSNLET00000034627.1; ENSNLEP00000034294.1; ENSNLEG00000004701.3.
DR GeneTree; ENSGT00940000157232; -.
DR OMA; GKTVIHG; -.
DR Proteomes; UP000001073; Chromosome 22a.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:UniProt.
DR CDD; cd00112; LDLa; 14.
DR Gene3D; 2.40.128.620; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 14.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722:SF11; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2; 1.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF00057; Ldl_recept_a; 13.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00192; LDLa; 15.
DR SMART; SM00135; LY; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 15.
DR SUPFAM; SSF63825; YWTD domain; 2.
DR PROSITE; PS01209; LDLRA_1; 8.
DR PROSITE; PS50068; LDLRA_2; 15.
DR PROSITE; PS51120; LDLRB; 5.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 52..90
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 93..129
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 297..333
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 334..372
FT /note="EGF-like calcium-binding"
FT /evidence="ECO:0000259|SMART:SM00179"
FT DOMAIN 337..372
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 422..464
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 465..507
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 579..618
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 641..682
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 683..726
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 727..770
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 818..859
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 911..947
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 953..989
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 993..1029
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DISULFID 14..26
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 21..39
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 33..48
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 94..106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 101..119
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 113..128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 138..156
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 150..165
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 169..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 176..194
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 188..203
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 208..220
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 215..233
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 227..242
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 871..883
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 878..896
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 890..905
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 912..924
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 919..937
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 931..946
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 954..966
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 961..979
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 973..988
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 994..1006
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1001..1019
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1013..1028
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1052..1067
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1116..1128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1123..1141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1135..1150
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1207 AA; 134790 MW; A35F5DBCCD7E90C1 CRC64;
LDNFLKFLSV IAECDSEHFR CGSGHCIPAD WRCDGTKDCS DDADEIGCAV VTCQQGYFRC
QSEGQCIPNS WVCDQDQDCD DGSDERQDCS QNTCSSHQIT CSNGQCIPSE YRCDHVRDCP
DGADENDCQY PTCEQLTCDN GACYNTSQKC DWKVDCRDSS DEVNCTEICL HNEFSCGSGE
CIPRAYVCDH DNDCQDGSDE HACNYPTCGG HQFTCPSGRC IYQNWVCDGE DDCKDNGDED
GCESSPHDVH KCSPREWSCP ESGRCISIYK VCDGILDCPG REDENSTTTG KYCSTTLCSA
LNCQYQCHET PYGGACFCPP GYIINHNDSR TCVEFDDCQI WGICDQKCES RPGHHLCHCE
EGYILERGQY CKANNSFGEA SIIFSNGRDL LIGDIHGRSF RILVESQNRG VAVGVAFHYH
LQRVFWTDTV QNKVFSVDIN GLNIQEVLNV SVETPENLAV DWVNNKIYLV ETKVNRIDMV
NLDGSYRVTL ITENLGHPRG IAVDPTVGKT VVHGGSLIPH PFGISLFEGQ VFFTDWTKMA
VLKANKFTET NPQVYYQASL RPYGVTVYHS LRQPYATNPC KDNNGGCEQV CVLSHRTDND
GLGFRCKCTF GFQLDTDERR EILAANRVEN VESLAFDWIS KNLYWTDSHY KSISVMRLAD
KTRRTVVQYL NNPRSVVVHP FAGYLFFTDW FRPAKIMRAW SDGSHLLPIV NTTLGWPNGL
AIDWAASRLY WVDAYFDKIE HSTFDGLDRR RLGHIEQMTH PFGLAIFGEY LFFTDWRLGA
IIRVRKADGG EMTVIRSGIA YILHLKSYDV NIQTGSNACN QPTHPNGDCS HFCFPVPNFQ
RVCGCPYGMK LASNHLTCEG DPTNEPPTEQ CGLFSFPCKN GRCVPNYYRC DGVDDCHDNS
DEQLCGTLNN TCSSSAFTCG HGECIPAHWR CDKRNDCVDG SDEHNCPTHA PASCLDTQYT
CDNHQCISKN WVCDTDNDCG DGSDEKNCNS TETCQPSQFN CPNHRCIDLS FVCDGDKDCV
DGSDEVGCVL NCTASQFKCA SGDKCISVTN RCDGVFDCSD NSDEAGCPTR PPGMCHSDEF
QCQEDGICIP NFWECDGHPD CLYGSDEHNA CVPKTCPSSY FHCDNGNCIH RAWLCDRDND
CGDMSDEKDC PTQPFRCPSW QWQCLGHNIC VNLSVVCDGI FDCPNGTDES PLCSKFPDHS
LLAINSF
//
