ID A0A2I3GTW6_NOMLE Unreviewed; 896 AA.
AC A0A2I3GTW6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Chromosome transmission fidelity factor 18 {ECO:0000313|Ensembl:ENSNLEP00000034798.1};
GN Name=CHTF18 {ECO:0000313|Ensembl:ENSNLEP00000034798.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000034798.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000034798.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000034798.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the activator 1 small subunits family. CTF18
CC subfamily. {ECO:0000256|ARBA:ARBA00043975}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01048010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GTW6; -.
DR Ensembl; ENSNLET00000046820.1; ENSNLEP00000034798.1; ENSNLEG00000008429.3.
DR GeneTree; ENSGT00550000075029; -.
DR Proteomes; UP000001073; Chromosome 18.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd18140; HLD_clamp_RFC; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047854; RFC_lid.
DR PANTHER; PTHR23389; CHROMOSOME TRANSMISSION FIDELITY FACTOR 18; 1.
DR PANTHER; PTHR23389:SF3; CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG; 1.
DR Pfam; PF00004; AAA; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 306..464
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 33..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 896 AA; 97806 MW; A273B8572A7E2AEA CRC64;
ASTPSPSGVP LSTAGRPPQT FEEALARGDA VSCPAPAASV GSSQGGARKR RVDADLQPAG
SLPHAPRIKR PRLQVVKRLN FRSEEMEEPP PPDSPPTDIT PPPSPEDLAE LWDHGYGAHP
VPWMRASDAA GDVAARNPVL RRPPILEDYV HVTSTEGVRA YLVLRADPMA TGVQVRGCGL
PARRVGQSPG VSLAVTHQQE DGGGHSSCGS ASHGARGSRW QADCPCLKSV PPFLSFPQFT
NRCLLKWLKL WDLVVFGHER PARKPRPSVE PARVCKEATA PGKWKSHEQV LEEMLEAGLD
PSQRPRQKVA LLCGPPGLGK TTLAHVIARH AGYSVVEMNA SDDRSPEVFR TRIEAATQMQ
AVLGAGGKPN CLVIDEIDGA PVAAINVLLS ILNRKGPQEV EPQGPAVPSG GGRRRRADGG
LLMRPIICIC NDQFAPSLRQ LKQQAFLLHF PPTLPSRLVQ RLQEVSLRQG MRADPGVLAA
LCEKTDNDIR ACINTLQFLY SRGQRELSVG DVQATRVGLK DQRRGLFSVW QEVFQLPRAQ
RRRVGQDPAP PADILLLGDG DVGSLTSASQ RFYRVLHATA SAGEHEKVVQ GLFDNFLRLR
LRDSSLGAVC AALDWLAFDD LLAGAAHHSQ SFQLLRYPPF LPVAFHVLFA SSHTPRITFP
SSQQEAQNRM SQMRNLIQTL VSGITPATRS RATPQALLLD ALCLLLDILA PKLRPVSWGT
PHLLPSPPCL LPSSPSLTYR QERTPDGQNV EELCRFPELP ARKPLTYQTK QLIAREIEVE
KMRRAEASAR AENSPQVDGS PPGLEGLLGG SGEKGVRRPA PRNHEQRLEH IMRRAAREEQ
VWNGSTAVLS AGDTAPEQDS VEQRMGTAVG RSEVWFRFNE GVSNAVRRSL YIRDLL
//
