ID A0A2I3GU30_NOMLE Unreviewed; 471 AA.
AC A0A2I3GU30;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Septin-4 {ECO:0000256|ARBA:ARBA00040438};
GN Name=SEPTIN4 {ECO:0000313|Ensembl:ENSNLEP00000034735.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000034735.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000034735.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000034735.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cytoplasmic vesicle, secretory vesicle
CC {ECO:0000256|ARBA:ARBA00004398}. Perikaryon
CC {ECO:0000256|ARBA:ARBA00004484}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|RuleBase:RU004560}.
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DR EMBL; ADFV01070582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01070583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3GU30; -.
DR Ensembl; ENSNLET00000052292.1; ENSNLEP00000034735.1; ENSNLEG00000008245.3.
DR GeneTree; ENSGT00390000018146; -.
DR Proteomes; UP000001073; Chromosome 14.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR CDD; cd01850; CDC_Septin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR PANTHER; PTHR18884:SF71; SEPTIN-4; 1.
DR Pfam; PF00735; Septin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023069};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004560};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 134..407
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
FT REGION 40..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 471 AA; 54388 MW; 1314E68F203B2A68 CRC64;
MDRSLGWQGN SVPEDRTEAG IKRFLEDTTD DGELSKFVKD FSGNESCHPP EAKTWASRPQ
APDLYDDDLE FRPPSWPQSS DNQQYFCAPA PLSPSARPRS PWGKLDPYDS SEDDKEYVGF
ATLPNQVHRK SVKKGFDFTL MVAGESGLGK STLVNSLFLT DLYRDRKLLG AEERIMQTVE
ITKHAVDIEE KGVRLRLTIV DTPGFGDAVN NTECWKPVAE YIDQQFEQYF RDESGLNRKN
IQDNRVHCCL YFISPFGHGL RPLDVEFMKA LHQRVNIVPI LAKADTLTPP EVDRKKRKIR
EEIEHFGIKI YQFPDCDSDE DEDFKLQDQA LKESIPFAVI GSNTVVEARG RRVRGRLYPW
GIVEVENPGH CDFVKLRTML VRTHMQDLKD VTRETHYENY RAQCIQSMTR LVVKERNRNK
LTRESGTDFP IPAVPPGTDP ETEKLIREKD EELRRMQEML HKIQKQMKET Y
//
