ID A0A2I3GUK3_NOMLE Unreviewed; 693 AA.
AC A0A2I3GUK3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Forkhead box P1 {ECO:0000313|Ensembl:ENSNLEP00000034932.1};
GN Name=FOXP1 {ECO:0000313|Ensembl:ENSNLEP00000034932.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000034932.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000034932.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000034932.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR EMBL; ADFV01025328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004091821.1; XM_004091773.2.
DR RefSeq; XP_012357647.1; XM_012502193.1.
DR AlphaFoldDB; A0A2I3GUK3; -.
DR SMR; A0A2I3GUK3; -.
DR STRING; 61853.ENSNLEP00000034932; -.
DR Ensembl; ENSNLET00000049235.1; ENSNLEP00000034932.1; ENSNLEG00000002497.2.
DR GeneTree; ENSGT00940000159892; -.
DR InParanoid; A0A2I3GUK3; -.
DR OMA; HEEHSHN; -.
DR Proteomes; UP000001073; Chromosome 21.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001046; F:core promoter sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0050681; F:nuclear androgen receptor binding; IEA:Ensembl.
DR GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0042118; P:endothelial cell activation; IEA:Ensembl.
DR GO; GO:0042116; P:macrophage activation; IEA:Ensembl.
DR GO; GO:0042117; P:monocyte activation; IEA:Ensembl.
DR GO; GO:0060766; P:negative regulation of androgen receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0002903; P:negative regulation of B cell apoptotic process; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0036035; P:osteoclast development; IEA:Ensembl.
DR GO; GO:0050861; P:positive regulation of B cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
DR GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:2000341; P:regulation of chemokine (C-X-C motif) ligand 2 production; IEA:Ensembl.
DR GO; GO:1900424; P:regulation of defense response to bacterium; IEA:Ensembl.
DR GO; GO:1901509; P:regulation of endothelial tube morphogenesis; IEA:Ensembl.
DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032651; P:regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:0032655; P:regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:1901256; P:regulation of macrophage colony-stimulating factor production; IEA:Ensembl.
DR GO; GO:0045655; P:regulation of monocyte differentiation; IEA:Ensembl.
DR GO; GO:0032680; P:regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR032354; FOXP-CC.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR PANTHER; PTHR45796:SF3; FORKHEAD BOX PROTEIN P1; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16159; FOXP-CC; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 465..551
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 465..551
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 693 AA; 77363 MW; 1177D1149A03373C CRC64;
MMQESGTETK SNGSAIQNGS GGSNHLLECG GLREGRSNGE TPAVDIGAAD LAHAQQQQQQ
ALQVARQLLL QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA MMTPQVITPQ QMQQILQQQV
LSPQQLQVLL QQQQALMLQQ QQLQEFYKKQ QEQLQLQLLQ QQHAGKQPKE QQQVATQQLA
FQQQLLQMQQ LQQQHLLSLQ RQGLLTIQPG QPALPLQPLA QGMIPTELQQ LWKEVTSAHT
AEETTGNNHS SLDLTTTCVS SSAPSKTSLI MNPHASTNGQ LSVHTPKRES LSHEEHPHSH
PLYGHGVCKW PGCEAVCEDF QSFLKHLNSE HALDDRSTAQ CRVQMQVVQQ LELQLAKDKE
RLQAMMTHLH VKSTEPKAAP QPLNLVSSVT LSKSASEASP QSLPHTPTTP TAPLTPVTQG
PSVITTTSMH TVGPIRRRYS DKYNVPISSA DIAQNQEFYK NAEVRPPFTY ASLIRQAILE
SPEKQLTLNE IYNWFTRMFA YFRRNAATWK GAIRTNLSLH KCFIRVEDEF GSFWTVDDEE
FKRGRHIQRG RPRKYCPDEN FDELVAHNPS LIKNMQSSHA YCTPLNAALQ ASMAENSIPL
YTTASMGNPT LGNLASAIRE ELNGAMEHTN SNESDSSPGR SPMQAVHPVH VKEEPLDPEE
AEGPLSLVTT ANHSPDFDHD RDYEDEPVNE DME
//
